| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4158275 | P | Octanol-PBS buffer partition coefficient, log D of the compound at pH 7.4 by HPLC method | 12 | small-molecule physicochemical format | Scientific Literature | |||
| 2. | ALA4158276 | F | Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 3. | ALA4158277 | F | Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method | Mus musculus | 13 | cell-based format | Scientific Literature | ||
| 4. | ALA4158278 | F | Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method relative to propionate | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 5. | ALA4158279 | F | Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method relative to propionate | Mus musculus | 13 | cell-based format | Scientific Literature | ||
| 6. | ALA4158280 | B | Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 7. | ALA4158282 | A | Fraction unbound in rat plasma at 5 uM after 4 hrs by equilibrium dialysis method | Rattus norvegicus | 9 | cell-free format | Scientific Literature | ||
| 8. | ALA4158283 | A | Fraction unbound in mouse plasma at 5 uM after 4 hrs by equilibrium dialysis method | Mus musculus | 9 | cell-free format | Scientific Literature | ||
| 9. | ALA4158284 | A | Unbound clearance in Sprague-Dawley rat at 1 mg/kg, iv administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
| 10. | ALA4158285 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
| 11. | ALA4158286 | A | Oral bioavailability in Sprague-Dawley rat at 3 mg/kg administered via gavage as single dose by LC-MS/MS analysis | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
| 12. | ALA4158287 | A | Dose normalized unbound AUC in Sprague-Dawley rat at 3 mg/kg, po administered via gavage as single dose by LC-MS/MS analysis | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
| 13. | ALA4158288 | A | Dose normalized unbound AUC in C57Bl/6J mouse at 50 mg/kg, po administered via gavage as single dose by LC-MS/MS analysis | Mus musculus | 8 | organism-based format | Scientific Literature | ||
| 14. | ALA4158290 | F | Antidiabetic activity in C57Bl/6J mouse assessed as inhibition of blood glucose AUC (0 to 120 mins) at 50 mg/kg, po treated prior to glucose challenge by OGTT relative to control | Mus musculus | 8 | organism-based format | Scientific Literature | ||
| 15. | ALA4158292 | F | Antidiabetic activity in FFA2R knock-out C57Bl/6J mouse assessed as inhibition of blood glucose AUC (0 to 120 mins) at 8.4 mg/kg, po treated prior to glucose challenge by OGTT | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4158293 | F | Agonist activity at human FFA2R expressed in CHOK1 cells assessed as cAMP accumulation at 10 uM relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4158294 | F | Antagonist activity at human FFA2R expressed in CHOK1 cells at 10 uM by cAMP accumulation assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4158295 | F | Antagonist activity at human FFA2R expressed in CHOK1 cells assessed as reduction in GTPgamma35S binding at 10 uM preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4158296 | F | Agonist activity at FFA1R (unknown origin) at 10 uM by aequorin based assay relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA4158297 | F | Antagonist activity at FFA1R (unknown origin) at 10 uM by aequorin based assay relative to control | Homo sapiens | 1 | assay format | Scientific Literature |
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