Antichlamydial activity against Chlamydia pneumoniae K7 infected in HL cells assessed as chlamydial inhibition at 50 uM after 70 hrs by fluorescent microscopic analysis
Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 20 mg/kg, po administered once daily for consecutive 5 days relative to control
Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 40 mg/kg, po administered once daily for consecutive 5 days relative to control
Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 20 mg/kg, sc administered once daily for consecutive 5 days relative to control (Rvb = 50.7%)
Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 40 mg/kg, sc administered once daily for consecutive 5 days relative to control (Rvb = 50.7%)
Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 20 mg/kg, ip administered once daily for consecutive 5 days relative to control (Rvb = 71.1%)
Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 40 mg/kg, ip administered once daily for consecutive 5 days relative to control (Rvb = 71.1%)
Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in mitotic figures at 40 mg/kg, ip administered once daily for consecutive 5 days by H and E staining microscopic analysis
Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in tumor weight at 20 mg/kg, po administered once daily for consecutive 5 days in presence of cisplatin relative to control
Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse assessed as reduction in number of mitotic figures at 20 mg/kg, po administered once daily for consecutive 5 days in presence of cisplatin by H and E staining microscopic analysis
Antitumor activity against mouse B16-F10 cells bearing C57BL/6 mouse bearing assessed as change in cleaved caspase-3 level in tumor at 20 mg/kg, po administered once daily for consecutive 5 days by immunostaining analysis
Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in body weight at 20 to 40 mg/kg, po administered once daily for consecutive 5 days
Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in body weight at 20 to 40 mg/kg, ip administered once daily for consecutive 5 days
Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in body weight at 20 to 40 mg/kg, sc administered once daily for consecutive 5 days