| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4158583 | Binding | Inhibition of RSV Long fusion protein assessed as protection against virus induced cytopathic effect in infected human Hep2 cells after 5 days by CCK8 assay | Respiratory syncytial virus | 48 | ALA4152381 | cell-based format | Scientific Literature | |
| 2. | ALA4158584 | ADME | Cytotoxicity against human Hep2 cells assessed as decrease in cell viability after 5 days by CCK8 assay | Homo sapiens | 48 | ALA4152381 | cell-based format | Scientific Literature | |
| 3. | ALA4158585 | Toxicity | Therapeutic index, ratio of CC50 for human Hep2 cells to EC50 for inhibition of RSV long fusion protein assessed as protection against virus induced cytopathic effect in infected human Hep2 cells | 48 | ALA4152381 | cell-based format | Scientific Literature | ||
| 4. | ALA4158586 | ADME | Effective permeability of the compound by PAMPA | 7 | ALA4152381 | assay format | Scientific Literature | ||
| 5. | ALA4158587 | ADME | Intrinsic clearance in rat liver microsomes | Rattus norvegicus | 11 | ALA4152381 | microsome format | Scientific Literature | |
| 6. | ALA4158588 | ADME | AUC (0 to infinity) in Wistar-Han rat at 2 mg/kg, iv after 15 mins to 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 5 | ALA4152381 | organism-based format | Scientific Literature | |
| 7. | ALA4158589 | ADME | AUC (0 to infinity) in Wistar-Han rat at 10 mg/kg, po after 15 mins to 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 5 | ALA4152381 | organism-based format | Scientific Literature | |
| 8. | ALA4158590 | ADME | Clearance in Wistar-Han rat at 2 mg/kg, iv after 15 mins to 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 5 | ALA4152381 | organism-based format | Scientific Literature | |
| 9. | ALA4158591 | ADME | Volume of distribution at steady state in Wistar-Han rat at 2 mg/kg, iv after 15 mins to 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 5 | ALA4152381 | organism-based format | Scientific Literature | |
| 10. | ALA4158592 | ADME | Oral bioavailability in Wistar-Han rat at 10 mg/kg after 15 mins to 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 5 | ALA4152381 | organism-based format | Scientific Literature | |
| 11. | ALA4158593 | ADME | Intrinsic clearance in human liver microsomes | Homo sapiens | 11 | ALA4152381 | microsome format | Scientific Literature | |
| 12. | ALA4158594 | ADME | Intrinsic clearance in mouse liver microsomes | Mus musculus | 11 | ALA4152381 | microsome format | Scientific Literature | |
| 13. | ALA4158599 | Physicochemical | Solubility of the compound by LYSA | 5 | ALA4152381 | small-molecule physicochemical format | Scientific Literature | ||
| 14. | ALA4158602 | ADME | Half life in Wistar-Han rat at 2 mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 5 | ALA4152381 | organism-based format | Scientific Literature | |
| 15. | ALA4158617 | Binding | Inhibition of RSV Long fusion protein L138F mutant assessed as protection against virus induced cytopathic effect in infected human Hep2 cells after 5 days by CCK8 assay | Respiratory syncytial virus | 2 | ALA4152381 | cell-based format | Scientific Literature | |
| 16. | ALA4158622 | ADME | Drug metabolism in rat liver microsomes assessed as dealkylation | Rattus norvegicus | 1 | ALA4152381 | microsome format | Scientific Literature | |
| 17. | ALA4158623 | ADME | Drug metabolism in mouse liver microsomes assessed as dealkylation | Mus musculus | 1 | ALA4152381 | microsome format | Scientific Literature | |
| 18. | ALA4158624 | ADME | Drug metabolism in mouse liver microsomes assessed as oxidation | Mus musculus | 1 | ALA4152381 | microsome format | Scientific Literature | |
| 19. | ALA4158625 | ADME | Drug metabolism in rat liver microsomes assessed as oxidation | Rattus norvegicus | 1 | ALA4152381 | microsome format | Scientific Literature |
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