| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4143838 | F | Antiviral activity against HCV infected in human Ava5 cells assessed as inhibition of viral RNA replication at 5 uM after 3 days by RT-qPCR method relative to control | Hepacivirus hominis | 25 | ALA4138248 | organism-based format | Scientific Literature | |
| 2. | ALA4143839 | F | Antiviral activity against HCV infected in human Ava5 cells assessed as inhibition of viral RNA replication at 20 uM after 3 days by RT-qPCR method relative to control | Hepacivirus hominis | 25 | ALA4138248 | organism-based format | Scientific Literature | |
| 3. | ALA4143840 | A | Cytotoxicity against human Ava5 cells assessed as cell viability at 20 uM after 72 hrs by XTT assay relative to control | Homo sapiens | 25 | ALA4138248 | cell-based format | Scientific Literature | |
| 4. | ALA4143841 | A | Cytotoxicity against human Ava5 cells assessed as cell viability at 200 uM after 72 hrs by XTT assay relative to control | Homo sapiens | 25 | ALA4138248 | cell-based format | Scientific Literature | |
| 5. | ALA4143842 | F | Antiviral activity against HCV infected in human Ava5 cells assessed as inhibition of viral RNA replication after 3 days by RT-qPCR method | Hepacivirus hominis | 4 | ALA4138248 | organism-based format | Scientific Literature | |
| 6. | ALA4143843 | A | Cytotoxicity against human Ava5 cells assessed as decrease in cell viability after 72 hrs by XTT assay | Homo sapiens | 4 | ALA4138248 | cell-based format | Scientific Literature | |
| 7. | ALA4143844 | T | Selectivity index, ratio of CC50 for human Ava5 cells to IC50 for HCV | 4 | ALA4138248 | assay format | Scientific Literature | ||
| 8. | ALA4143845 | F | Potency index, ratio of ribavirin IC50 to test compound IC50 for HCV | Hepacivirus hominis | 1 | ALA4138248 | organism-based format | Scientific Literature | |
| 9. | ALA4143846 | F | Antiviral activity against HCV infected in human Ava5 cells assessed as inhibition of NS5B protein synthesis after 3 days by Western blot method | Hepacivirus hominis | 1 | ALA4138248 | organism-based format | Scientific Literature | |
| 10. | ALA4143847 | F | Antiviral activity against HCV infected in human Ava5 cells assessed as inhibition of viral RNA replication after 3 days by RT-qPCR method | Hepacivirus hominis | 1 | ALA4138248 | organism-based format | Scientific Literature | |
| 11. | ALA4143848 | F | Antiviral activity against HCV JFH-1 infected in human Huh7.5 cells assessed as inhibition of viral RNA replication after 3 days by RT-qPCR method | Hepacivirus hominis | 1 | ALA4138248 | organism-based format | Scientific Literature | |
| 12. | ALA4143849 | B | Induction of HO1 (unknown origin) promoter activity expressed in human Ava5 cells transfected with pHO-1-Luc after 3 days | Not specified | 1 | ALA4138248 | cell-based format | Scientific Literature | |
| 13. | ALA4143850 | F | Upregulation of HO-1 protein expression in human Ava5 cells after 3 days by Western blot method | Homo sapiens | 1 | ALA4138248 | cell-based format | Scientific Literature | |
| 14. | ALA4143851 | F | Antiviral activity against HCV infected in human Ava5 cells assessed as inhibition of NS5B protein synthesis at 1 uM after 3 days in presence of HO-1 inhibitor SnPP by Western blot method | Hepacivirus hominis | 1 | ALA4138248 | organism-based format | Scientific Literature | |
| 15. | ALA4143852 | F | Antiviral activity against HCV infected in human Ava5 cells assessed as inhibition of viral RNA replication at 1 uM after 3 days in presence of HO-1 inhibitor SnPP by RT-qPCR method | Hepacivirus hominis | 1 | ALA4138248 | organism-based format | Scientific Literature | |
| 16. | ALA4143853 | F | Effect on Nrf2 protein expression in human Ava5 cells at 0.5 to 1 uM after 3 days by Western blot method | Homo sapiens | 1 | ALA4138248 | cell-based format | Scientific Literature | |
| 17. | ALA4143854 | F | Effect on Keap-1 protein expression in human Ava5 cells at 0.5 to 1 uM after 3 days by Western blot method | Homo sapiens | 1 | ALA4138248 | cell-based format | Scientific Literature | |
| 18. | ALA4143855 | F | Downregulation of bach-1 protein expression in human Ava5 cells after 3 days by Western blot method | Homo sapiens | 1 | ALA4138248 | cell-based format | Scientific Literature | |
| 19. | ALA4143856 | B | Induction of bach-1 translocation into nucleus of human Ava5 cells after 3 days by Western blot method | Homo sapiens | 1 | ALA4138248 | assay format | Scientific Literature | |
| 20. | ALA4143857 | B | Induction of Nrf2-mediated ARE transactivation in human Ava5 cells transfected with p2xARE-Luc after 3 days | Homo sapiens | 1 | ALA4138248 | cell-based format | Scientific Literature |
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