| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4131164 | B | Substrate activity at recombinant human NQO1 expressed in Escherichia coli assessed as reduction rate by measuring umol of NADPH utilized per umol of enzyme at 10 uM preincubated for 3 mins followed by NADPH addition measured at 2 secs interval for 5 mins by UV-Vis spectroscopy | Homo sapiens | 23 | assay format | Scientific Literature | ||
| 2. | ALA4131165 | A | Substrate activity at human CPR expressed in baculovirus expression system assessed as reduction rate by measuring umol of NADPH utilized per umol of enzyme at 10 uM preincubated for 3 mins followed by NADPH addition measured at 2 secs interval for 5 mins by UV-Vis spectroscopy | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 3. | ALA4131166 | B | Selectivity ratio for substrate activity at recombinant human NQO1 to substrate activity at human CPR | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 4. | ALA4131167 | P | Lipophilicity, log D of the compound at pH 7.4 | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA4131168 | P | Intrinsic solubility of the compound | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4131169 | P | Solubility of the compound in diluted HCl buffer at pH 3 | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 7. | ALA4131170 | A | Effective permeability of the compound at pH 7.4 by PAMPA assay | 8 | assay format | Scientific Literature | |||
| 8. | ALA4131171 | B | Substrate activity at recombinant human NQO1 expressed in Escherichia coli assessed as Kcat to Km ratio at 10 uM preincubated for 3 mins followed by NADPH addition measured at 2 secs interval for 5 mins by UV-Vis spectroscopy | Homo sapiens | 8 | assay format | Scientific Literature |
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