| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4140603 | B | Inhibition of COX1 in mouse BV2 cells assessed as reduction in LPS-stimulated PGE2 release by measuring PGE2 level at 10 uM preincubated for 1 hr followed by LPS addition measured after 48 hrs by immunoassay (Rvb = 0.7555 +/- 0.032 ng/ml) | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA4140604 | A | Apparent permeability across basolateral to apical side in human Caco2 cells assessed as GLUT1-mediated drug transport at 100 uM after 120 mins by UV-Visible spectroscopic method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA4140605 | A | Apparent permeability across basolateral to apical side in human Caco2 cells assessed as GLUT1-mediated drug transport at 100 uM after 120 mins in presence of GLUT1 inhibitor phloretin by UV-Visible spectroscopic method | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA4140606 | A | Apparent permeability across apical to basolateral side in human Caco2 cells at 100 uM after 120 mins by UV-Visible spectroscopic method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 5. | ALA4140607 | A | Apparent permeability across apical to basolateral side in human Caco2 cells at 100 uM after 120 mins in presence of GLUT1 inhibitor phloretin by UV-Visible spectroscopic method | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA4140608 | A | Permeability across basolateral to apical side in human Caco2 cells assessed as GLUT1-mediated drug transport by immunofluorescence method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 7. | ALA4140609 | A | Permeability across basolateral to apical side in human Caco2 cells assessed as GLUT1-mediated drug transport by transportability method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 8. | ALA4140611 | A | Inhibition of GLUT1-mediated 2NBDG uptake in human Caco2 cells at 0.01 to 0.1 mM after 10 mins by Hoechst 33342 staining based fluorescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4140612 | F | Cell cycle arrest in human Caco2 cells assessed as accumulation at S-phase at 100 uM after 24 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA4140613 | F | Cell cycle arrest in human Caco2 cells assessed as accumulation at G2/M-phase at 100 uM after 24 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA4140614 | F | Cell cycle arrest in human Caco2 cells assessed as accumulation at G0/G1-phase at 100 uM after 24 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4140615 | B | Inhibition of human COX1 assessed as reduction in appearance of oxidized TMPD using arachidonic acid as substrate by colorimetric assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 13. | ALA4140616 | B | Inhibition of human COX1 assessed as reduction in appearance of oxidized TMPD at 50 uM using arachidonic acid as substrate by colorimetric assay relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 14. | ALA4140617 | B | Inhibition of human COX2 assessed as reduction in appearance of oxidized TMPD using arachidonic acid as substrate by colorimetric assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 15. | ALA4140618 | B | Inhibition of human COX2 assessed as reduction in appearance of oxidized TMPD at 50 uM using arachidonic acid as substrate by colorimetric assay relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 16. | ALA4140619 | B | Selectivity index, ratio of IC50 for inhibition of human COX2 to IC50 for inhibition of human COX1 | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 17. | ALA4140620 | B | Inhibition of COX1 in mouse BV2 cells assessed as reduction in LPS-stimulated PGE2 release by measuring PGE2 level at 0.5 uM preincubated for 1 hr followed by LPS addition measured after 48 hrs by immunoassay (Rvb = 0.7555 +/- 0.032 ng/ml) | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA4140621 | B | Inhibition of COX1 in mouse BV2 cells assessed as reduction in LPS-stimulated PGE2 release by measuring PGE2 level at 1 uM preincubated for 1 hr followed by LPS addition measured after 48 hrs by immunoassay (Rvb = 0.7555 +/- 0.032 ng/ml) | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4140622 | A | Chemical stability in pH 1 simulated gastric fluid at 2.5 mg/ml after 60 mins by HPLC analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 20. | ALA4140623 | A | Chemical stability in pH 7.3 simulated blood fluid at 2.5 mg/ml after 60 mins by HPLC analysis | 1 | small-molecule physicochemical format | Scientific Literature |
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