| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4158441 | B | Antagonist activity at human TRPV4 expressed in BHK/AC9 or HEK MSR2 cells assessed as inhibition of PF-04674114-induced Ca2+ flux pre-incubated for 10 mins before agonist addition by FLIPR assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 2. | ALA4158442 | P | Aqueous solubility of the compound | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA4158443 | A | Clearance in iv dosed Sprague-Dawley rat | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 4. | ALA4158444 | A | Unbound clearance in Sprague-Dawley rat | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 5. | ALA4158445 | A | MRT in iv dosed Sprague-Dawley rat | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 6. | ALA4158446 | A | Oral bioavailability in Sprague-Dawley rat | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 7. | ALA4158447 | A | Fraction unbound in Sprague-Dawley rat plasma | Rattus norvegicus | 3 | cell-free format | Scientific Literature | ||
| 8. | ALA4158448 | B | Inhibition of TRPA1 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA4158449 | B | Inhibition of TRPV1 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA4158450 | B | Inhibition of TRPM2 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA4158451 | B | Inhibition of TRPM4 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA4158452 | B | Inhibition of TRPM8 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA4158453 | B | Inhibition of TRPC3 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA4158454 | B | Inhibition of TRPC4 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA4158455 | B | Inhibition of TRPC5 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4158456 | B | Inhibition of TRPC6 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA4158464 | P | Lipophilicity, log D of the compound by chromatography | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 18. | ALA4322929 | P | Solubility of the compound in FaSSIF measured after 4 hrs | 13 | small-molecule physicochemical format | Scientific Literature | |||
| 19. | ALA4322932 | A | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv administered as 30 mins infusion or 1 to 2 mg/kg, po by HPLC-MS/MS analysis | Rattus norvegicus | 11 | organism-based format | Scientific Literature | ||
| 20. | ALA4322936 | A | Unbound volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv administered as 30 mins infusion or 1 to 2 mg/kg, po by HPLC-MS/MS analysis | Rattus norvegicus | 11 | organism-based format | Scientific Literature |
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