# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4151511 | B | Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux at 50 uM incubated for 5 mins by fluorescence based assay | Staphylococcus aureus | 44 | ALA4145675 | single protein format | Scientific Literature | |
2. | ALA4151512 | B | Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux incubated for 5 mins by fluorescence based assay | Staphylococcus aureus | 44 | ALA4145675 | single protein format | Scientific Literature | |
3. | ALA4151513 | A | Antimicrobial activity against Staphylococcus aureus SA-1199B expressing wild type norA and co-expressing GrlA A116E mutant by microdilution method | Staphylococcus aureus | 44 | ALA4145675 | organism-based format | Scientific Literature | |
4. | ALA4151514 | B | Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as minimal potentiating drug concentration causing 8 fold reduction in ciprofloxacin MIC by microdilution method based Checkerboard assay | Staphylococcus aureus | 44 | ALA4145675 | single protein format | Scientific Literature | |
5. | ALA5135900 | T | Cytotoxicity against HEL 299 cells assessed as reduction in cell viability measured after 1 to 2 hrs by MTS colorimetric assay | Homo sapiens | 14 | ALA5131518 | cell-based format | Scientific Literature | |
6. | ALA5135901 | F | Antiviral activity against SARS-CoV-2 infected in eGFP expressing African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect measured after 4 days post infection by laser scanning microscopic analysis | Severe acute respiratory syndrome coronavirus 2 | 42 | ALA5131518 | organism-based format | Scientific Literature | |
7. | ALA5135902 | T | Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 1 to 2 hrs by MTS colorimetric assay | Chlorocebus sabaeus | 29 | ALA5131518 | cell-based format | Scientific Literature | |
8. | ALA5135903 | T | Selectivity index, ratio of CC50 for cytotoxicity against African green monkey Vero E6 cells to EC50 for antiviral activity against SARS-CoV-2 infected in eGFP expressing African green monkey Vero E6 cells | 18 | ALA5131518 | cell-based format | Scientific Literature | ||
9. | ALA5135904 | F | Antiviral activity against HCoV-229E infected in HEL 299 cells assessed as reduction in virus-induced cytopathic effect preincubated with compound followed by viral infection and measured after 7 days by MTS cell viability assay | Human coronavirus 229E | 14 | ALA5131518 | organism-based format | Scientific Literature | |
10. | ALA5135905 | T | Selectivity index, ratio of CC50 for cytotoxicity against HEL 299 cells to EC50 for antiviral activity against HCoV-229E infected in HEL 299 cells | 14 | ALA5131518 | cell-based format | Scientific Literature | ||
11. | ALA5135906 | F | Antiviral activity against HCoV-OC43 infected in HEL 299 cells assessed as reduction in virus-induced cytopathic effect preincubated with compound followed by viral infection and measured after 7 days by MTS cell viability assay | Human coronavirus OC43 | 14 | ALA5131518 | cell-based format | Scientific Literature | |
12. | ALA5135907 | T | Selectivity index, ratio of CC50 for cytotoxicity against HEL 299 cells to EC50 for antiviral activity against HCoV-OC43 infected in HEL 299 cells | 14 | ALA5131518 | cell-based format | Scientific Literature |