| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4132895 | F | Antiproliferative activity against human KMS11 cells over-expressing GFP after 72 hrs by CellTiter-Glo assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 2. | ALA4132896 | A | Inhibition of human GLUT1 in human KMS11 cells over-expressing human GLUT1 assessed as as inhibition of receptor-mediated cell proliferation after 72 hrs by CellTiter-Glo assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 3. | ALA4132897 | F | Cytotoxicity against human KMS11 cells after 72 hrs by AnnexinV/DAPI staining-based flow cytometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4132898 | B | Antagonist activity at GLUT4 in human JJN3 cells assessed as reduction in [3H]2-deoxy-D-glucose uptake preincubated for 5 to 6 mins followed by [3H]2-deoxy-D-glucose addition measured after 4 to 6 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4132899 | F | Inhibition of [3H]2-deoxy-D-glucose uptake in human JJN-3 cells transfected with GLUT4 shRNA preincubated for 5 to 6 mins followed by [3H]2-deoxy-D-glucose addition measured after 4 to 6 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4132900 | F | Antiproliferative activity against human JJN-3 cells transfected with GLUT4 shRNA assessed as growth inhibition at 15 uM aftter 72 hrs by trypan blue dye-based cell counting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4132901 | A | Antagonist activity at human GLUT1 expressed in HEK293 cells transfected with GLUT1 shRNA assessed as inhibition of [3H]2-deoxy-D-glucose uptake preincubated for 5 mins followed by [3H]2-deoxy-D-glucose addition and measured after 6 mins | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 8. | ALA4132902 | A | Antagonist activity at human GLUT3 expressed in HEK293 cells transfected with GLUT1 shRNA assessed as inhibition of [3H]2-deoxy-D-glucose uptake preincubated for 5 mins followed by [3H]2-deoxy-D-glucose addition and measured after 6 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4132903 | B | Antagonist activity at human GLUT4 expressed in HEK293 cells transfected with GLUT1 shRNA assessed as inhibition of [3H]2-deoxy-D-glucose uptake preincubated for 5 mins followed by [3H]2-deoxy-D-glucose addition and measured after 6 mins | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA4132904 | A | Antagonist activity at human GLUT8 expressed in HEK293 cells transfected with GLUT1 shRNA assessed as inhibition of [3H]2-deoxy-D-glucose uptake preincubated for 5 mins followed by [3H]2-deoxy-D-glucose addition and measured after 6 mins | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA4132905 | A | Displacement of ATB-BMPA from rat C-terminal 6His/Myc-tagged GLUT1 expressed in HEK293 cell low density microsome assessed as ATB-BMPA binding level at 20 uM preincubated for 10 mins followed by ATB-BMPA addition measured after 10 mins relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4132906 | B | Displacement of ATB-BMPA from rat C-terminal 6His/Myc-tagged GLUT4 expressed in HEK293 cell low density microsome assessed as ATB-BMPA binding level at 20 uM preincubated for 10 mins followed by ATB-BMPA addition measured after 10 mins relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4132909 | B | Antagonist activity at GLUT4 in human L363 cells assessed as reduction in MCL-1 protein expression at 15 uM after 18 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4132910 | B | Antagonist activity at GLUT4 in human JJN-3 cells assessed as reduction in MCL-1 protein expression at 15 uM after 18 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4132911 | B | Antagonist activity at GLUT4 in human L393 cells assessed as increase in sensitivity to ABT-199-induced cytotoxicity by measuring cell death at 10 uM after 72 hrs by CellTiter-Glo assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4132912 | B | Antagonist activity at GLUT4 in human JJN-3 cells assessed as increase in sensitivity to ABT-199-induced cytotoxicity by measuring cell death at 10 uM after 72 hrs by CellTiter-Glo assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4132913 | B | Antagonist activity at GLUT4 in multiple myeloma patient derived CD38+ and phyocerythrin-negative myeloma cells assessed as increase in sensitivity to ABT-199-induced cytotoxicity by measuring cell death at 10 uM after 48 hrs by CellTiter-Glo assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA4132914 | B | Antagonist activity at GLUT4 in human MM1S cells assessed as increase in sensitivity to dexamethasone-induced cytotoxicity by measuring cell death at 10 uM after 72 hrs by CellTiter-Glo assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4132915 | B | Antagonist activity at GLUT4 in multiple myeloma patient derived CD38+ and phyocerythrin-negative myeloma cells assessed as increase in sensitivity to dexamethasone-induced cytotoxicity by measuring cell death at 10 uM after 48 hrs by CellTiter-Glo assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA4132916 | A | Cytotoxicity in multiple myeloma patient derived CD38(-)/CD45(-) non-myeloma bone marrow cells at 10 uM in presence of ABT-199 incubated for 48 hrs by CellTiter-Glo assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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