# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4134140 | F | Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
2. | ALA4134141 | B | Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
3. | ALA4134142 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining measured at 10 mins | Homo sapiens | 6 | microsome format | Scientific Literature | ||
4. | ALA4134143 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining measured at 10 mins | Mus musculus | 6 | microsome format | Scientific Literature | ||
5. | ALA4134144 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining measured at 10 mins | Rattus norvegicus | 5 | microsome format | Scientific Literature | ||
6. | ALA4134145 | F | Agonist activity at mouse GPR120 by calcium flux assay | Mus musculus | 2 | assay format | Scientific Literature | ||
7. | ALA4134146 | F | Agonist activity at human GPR40 by calcium flux assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
8. | ALA4134147 | F | Antidiabetic activity in diet-induced obese C57BL/6 mouse assessed as reduction in plasma glucose delta AUC level at 1 mg/kg, po administered 30 mins prior to glucose challenge measured 90 mins post glucose challenge by OGTT relative to control | Mus musculus | 2 | organism-based format | Scientific Literature | ||
9. | ALA4134148 | F | Antidiabetic activity in diet-induced obese C57BL/6 mouse assessed as reduction in plasma glucose delta AUC level at 3 mg/kg, po administered 30 mins prior to glucose challenge measured 90 mins post glucose challenge by OGTT relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
10. | ALA4134149 | F | Antidiabetic activity in diet-induced obese C57BL/6 mouse assessed as reduction in plasma glucose delta AUC level administered orally 30 mins prior to glucose challenge measured 90 mins post glucose challenge by OGTT | Mus musculus | 1 | organism-based format | Scientific Literature | ||
11. | ALA4134150 | F | Antidiabetic activity in diet-induced obese C57BL/6 mouse harboring wild type GPR120 assessed as reduction in plasma glucose delta AUC level at 60 mg/kg, po qd administered 30 mins prior to glucose challenge measured 90 mins post glucose challenge for 3 weeks | Mus musculus | 1 | organism-based format | Scientific Literature | ||
12. | ALA4134151 | F | Antidiabetic activity in diet-induced obese C57BL/6 mouse assessed as reduction in plasma glucose delta AUC level at 0.3 mg/kg, po administered 30 mins prior to glucose challenge measured 90 mins post glucose challenge by OGTT relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
13. | ALA4134152 | F | Antidiabetic activity in diet-induced obese C57BL/6 mouse assessed as reduction in plasma glucose delta AUC level at 0.1 mg/kg, po administered 30 mins prior to glucose challenge measured 90 mins post glucose challenge by OGTT relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
14. | ALA4134153 | F | Antidiabetic activity in GPR120 knockout diet-induced obese C57BL/6 mouse assessed as reduction in plasma glucose delta AUC level at 60 mg/kg, po qd administered 30 mins prior to glucose challenge measured 90 mins post glucose challenge for 3 weeks | Mus musculus | 1 | organism-based format | Scientific Literature | ||
15. | ALA4134154 | A | Inhibition of CYP450 (unknown origin) measured up to 10 uM | Homo sapiens | 1 | assay format | Scientific Literature | ||
16. | ALA4134155 | B | Activation of PXR (unknown origin) at 5 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
17. | ALA4134156 | B | Inhibition of human ERG | Homo sapiens | 1 | single protein format | Scientific Literature | ||
18. | ALA4134157 | B | Inhibition of human ERG at 3 uM by patch express assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
19. | ALA4134158 | B | Inhibition of human ERG at 10 uM by patch express assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
20. | ALA4134159 | B | Inhibition of human ERG at 30 uM by patch express assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature |