# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4152830 | B | Binding affinity to wild-type human partial length ALK (I1088 to E1409 residues) expressed in mammalian expression system by KINOMEscan assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
2. | ALA4152831 | B | Inhibition of ALK autophosphorylation at Y1507 residue in human SU-DHL1 cells after 16 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
3. | ALA4152832 | B | Inhibition of ALK autophosphorylation at Y1507 residue in human NCI-H2228 cells after 16 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4152833 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human SU-DHL1 cells assessed as reduction in STAT3 phosphorylation at Y705 residue after 16 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
5. | ALA4152834 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human NCI-H2228 cells assessed as reduction in STAT3 phosphorylation at Y705 residue after 16 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4152835 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated NPM-ALK fusion protein degradation in human SU-DHL1 cells assessed as reduction in NPM-ALK fusion protein levels after 16 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
7. | ALA4152836 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated NPM-ALK fusion protein degradation in human SU-DHL1 cells assessed as reduction in NPM-ALK fusion protein levels at 100 nM after 16 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA4152837 | B | Inhibition of ALK autophosphorylation at Y1507 residue in human SU-DHL1 cells at 100 nM after 16 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA4152838 | B | Inhibition of ALK in human SU-DHL1 cells assessed as reduction in STAT3 phosphorylation at Y705 residue at 100 nM after 16 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA4152839 | T | Toxicity against human SU-DHL1 cells assessed as cell death over 100 nM after 3 days by luminescence-based CellTiter-Glo assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
11. | ALA4152843 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human NCI-H2228 cells assessed as reduction in EML4-ALK fusion protein levels after 16 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
12. | ALA4152844 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human NCI-H2228 cells assessed as reduction in EML4-ALK fusion protein levels at 100 nM after 16 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
13. | ALA4152845 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human SU-DHL1 cells assessed as reduction in ALK autophosphorylation at Y1507 residue at 30 nM after 2 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
14. | ALA4152846 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human SU-DHL1 cells assessed as reduction in STAT3 phosphorylation at Y705 residue at 30 nM after 2 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
15. | ALA4152847 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human SU-DHL1 cells assessed as reduction in NPM-ALK fusion protein levels at 30 nM measured up to 4 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
16. | ALA4152848 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human NCI-H2228 cells assessed as reduction in EML4-ALK fusion protein levels at 60 nM after 8 to 24 hrs hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
17. | ALA4152849 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation assessed as inhibition of ALK autophosphorylation at Y1507 residue in human NCI-H2228 cells at 60 nM after 8 to 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
18. | ALA4152850 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated NPM-ALK fusion protein degradation in human SU-DHL1 cells pretreated with MLN4924 for 2 hrs followed by compound addition at 100 nM and measured after 6 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
19. | ALA4152851 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated NPM-ALK fusion protein degradation in human SU-DHL1 cells pretreated with MG-132 for 2 hrs followed by compound addition at 100 nM and measured after 6 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
20. | ALA4152852 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated NPM-ALK fusion protein degradation in human SU-DHL1 cells pretreated with pomalidomide for 2 hrs followed by compound addition at 100 nM and measured after 6 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |