# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4157512 | Binding | Inhibition of Cy5-labeled cyclosporin A binding to full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) after 30 mins by TR-FRET assay | Homo sapiens | 23 | ALA4152348 | assay format | Scientific Literature | |
2. | ALA4157513 | Functional | Antiviral activity against HCV genotype 2a infected in human HuH7 cells after 3 days by dual-glo luciferase reporter gene assay | Hepacivirus hominis | 22 | ALA4152348 | organism-based format | Scientific Literature | |
3. | ALA4157514 | ADME | Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 4 to 5 days by cell-titer glo assay | Homo sapiens | 21 | ALA4152348 | cell-based format | Scientific Literature | |
4. | ALA4157515 | ADME | Unbound fraction in cell culture medium/buffer dialysis at 2 uM at pH 7.4 by LC/MS/MS analysis | 18 | ALA4152348 | assay format | Scientific Literature | ||
5. | ALA4157516 | ADME | Unbound fraction in human plasma at 2 uM at pH 7.4 by LC/MS/MS analysis | Homo sapiens | 18 | ALA4152348 | cell-free format | Scientific Literature | |
6. | ALA4157517 | ADME | Half life in human plasma at 2 uM up to 4 hrs by LC/MS/MS analysis | Homo sapiens | 11 | ALA4152348 | cell-free format | Scientific Literature | |
7. | ALA4157518 | ADME | Half life in dog plasma at 2 uM up to 4 hrs by LC/MS/MS analysis | Canis lupus familiaris | 11 | ALA4152348 | cell-free format | Scientific Literature | |
8. | ALA4157519 | ADME | Half life in rat plasma at 2 uM up to 4 hrs by LC/MS/MS analysis | Rattus norvegicus | 8 | ALA4152348 | cell-free format | Scientific Literature | |
9. | ALA4157520 | ADME | Apparent permeability across apical to basolateral side in human Caco2 cells measured at 60 to 120 mins by LC/MS/MS analysis | Homo sapiens | 17 | ALA4152348 | cell-based format | Scientific Literature | |
10. | ALA4157521 | ADME | Apparent permeability across basolateral to apical side in human Caco2 cells measured at 60 to 120 mins by LC/MS/MS analysis | Homo sapiens | 17 | ALA4152348 | cell-based format | Scientific Literature | |
11. | ALA4157522 | Physicochemical | Lipophilicity, log D of the compound at pH 7.4 after 30 mins by HPLC/UV analysis | 17 | ALA4152348 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA4157534 | ADME | Oral bioavailability in Beagle dog at 5 mg/kg by HPLC/MS analysis | Canis lupus familiaris | 3 | ALA4152348 | organism-based format | Scientific Literature | |
13. | ALA4157535 | Toxicity | Therapeutic index, ratio of CC50 for human MT4 cells to EC50 for HCV genotype 2a infected in human HuH7 cells | 6 | ALA4152348 | cell-based format | Scientific Literature |