| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4157512 | B | Inhibition of Cy5-labeled cyclosporin A binding to full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) after 30 mins by TR-FRET assay | Homo sapiens | 23 | assay format | Scientific Literature | ||
| 2. | ALA4157513 | F | Antiviral activity against HCV genotype 2a infected in human HuH7 cells after 3 days by dual-glo luciferase reporter gene assay | Hepacivirus hominis | 22 | organism-based format | Scientific Literature | ||
| 3. | ALA4157514 | A | Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 4 to 5 days by cell-titer glo assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 4. | ALA4157515 | A | Unbound fraction in cell culture medium/buffer dialysis at 2 uM at pH 7.4 by LC/MS/MS analysis | 18 | assay format | Scientific Literature | |||
| 5. | ALA4157516 | A | Unbound fraction in human plasma at 2 uM at pH 7.4 by LC/MS/MS analysis | Homo sapiens | 18 | cell-free format | Scientific Literature | ||
| 6. | ALA4157517 | A | Half life in human plasma at 2 uM up to 4 hrs by LC/MS/MS analysis | Homo sapiens | 11 | cell-free format | Scientific Literature | ||
| 7. | ALA4157518 | A | Half life in dog plasma at 2 uM up to 4 hrs by LC/MS/MS analysis | Canis lupus familiaris | 11 | cell-free format | Scientific Literature | ||
| 8. | ALA4157519 | A | Half life in rat plasma at 2 uM up to 4 hrs by LC/MS/MS analysis | Rattus norvegicus | 8 | cell-free format | Scientific Literature | ||
| 9. | ALA4157520 | A | Apparent permeability across apical to basolateral side in human Caco2 cells measured at 60 to 120 mins by LC/MS/MS analysis | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 10. | ALA4157521 | A | Apparent permeability across basolateral to apical side in human Caco2 cells measured at 60 to 120 mins by LC/MS/MS analysis | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 11. | ALA4157522 | P | Lipophilicity, log D of the compound at pH 7.4 after 30 mins by HPLC/UV analysis | 17 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA4157534 | A | Oral bioavailability in Beagle dog at 5 mg/kg by HPLC/MS analysis | Canis lupus familiaris | 3 | organism-based format | Scientific Literature | ||
| 13. | ALA4157535 | T | Therapeutic index, ratio of CC50 for human MT4 cells to EC50 for HCV genotype 2a infected in human HuH7 cells | 6 | cell-based format | Scientific Literature |
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