| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4151319 | B | Inhibition of recombinant human MMP12 catalytic domain using Mca-PLGL-DpaAR-NH2 as substrate by fluorescence spectrophotometric method | Homo sapiens | 2 | ALA4145666 | single protein format | Scientific Literature | |
| 2. | ALA4151321 | B | Inhibition of APMA activated recombinant human full length MMP2 expressed in mouse cells using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate by fluorescence spectrophotometric method | Homo sapiens | 2 | ALA4145666 | cell-based format | Scientific Literature | |
| 3. | ALA4151324 | B | Inhibition of recombinant human MMP8 catalytic domain (Phe99 to Gln269 residues) expressed in Escherichia coli using McaKPLGL-Dpa-AR-NH2 as substrate by fluorescence spectrophotometric method | Homo sapiens | 2 | ALA4145666 | assay format | Scientific Literature | |
| 4. | ALA4151328 | B | Inhibition of recombinant human C-terminal His6-tagged ADAM17 (Arg215 to Asn671 residues) expressed in baculovirus infected Sf21 cells using Mca-PLAQAV-Dpa-RSSSR-NH2 as substrate by fluorescence spectrophotometric method | Homo sapiens | 2 | ALA4145666 | cell-based format | Scientific Literature | |
| 5. | ALA4151329 | B | Inhibition of recombinant human MMP1 catalytic domain (Phe100 to Gln268 residues) expressed in Escherichia coli at 10 uM using McaKPLGL-Dpa-AR-NH2 as substrate by fluorescence spectrophotometric method | Homo sapiens | 1 | ALA4145666 | assay format | Scientific Literature | |
| 6. | ALA4151330 | B | Inhibition of recombinant human MMP3 catalytic domain expressed in Escherichia coli at 10 uM using MOCAc-Arg-Pro-LysPro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as substrate by fluorescence spectrophotometric method relative to control | Homo sapiens | 1 | ALA4145666 | assay format | Scientific Literature | |
| 7. | ALA4151331 | B | Inhibition of recombinant human MMP7 expressed in Escherichia coli using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate at 10 uM by fluorescence spectrophotometric method | Homo sapiens | 1 | ALA4145666 | assay format | Scientific Literature | |
| 8. | ALA4151332 | B | Inhibition of recombinant human MMP9 catalytic domain (Phe107 to Pro449 residues) expressed in Escherichia coli using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate at 10 uM by fluorescence spectrophotometric method relative to control | Homo sapiens | 1 | ALA4145666 | assay format | Scientific Literature | |
| 9. | ALA4151333 | B | Inhibition of recombinant human MMP14 catalytic domain (89 to 265 residues) expressed in Escherichia coli using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate at 10 uM by fluorescence spectrophotometric method relative to control | Homo sapiens | 1 | ALA4145666 | assay format | Scientific Literature | |
| 10. | ALA4151334 | B | Inhibition of recombinant human C-terminal His10-tagged ADAM9 (Ala206 to Asp697 residues) expressed in mouse cells using McaPLAQAV-Dpa-RSSSR-NH2 as substrate at 10 uM by fluorescence spectrophotometric method relative to control | Homo sapiens | 1 | ALA4145666 | cell-based format | Scientific Literature | |
| 11. | ALA4151335 | B | Inhibition of recombinant human C-terminal His10-tagged ADAM10 (Thr214 to Glu672 residues) expressed in baculovirus infected Sf21 cells using McaKPLGL-Dpa-AR-NH2 as substrate by fluorescence spectrophotometric method | Homo sapiens | 1 | ALA4145666 | cell-based format | Scientific Literature | |
| 12. | ALA4151336 | A | Elimination half life in CD-1 mouse brain at 10 mg/kg, ip by UPLC analysis | Mus musculus | 1 | ALA4145666 | organism-based format | Scientific Literature | |
| 13. | ALA4151337 | A | Primary phase half life in CD-1 mouse brain at 10 mg/kg, ip by UPLC analysis | Mus musculus | 1 | ALA4145666 | organism-based format | Scientific Literature | |
| 14. | ALA4151338 | A | Time at which plasma concentration stays above in-vitro Ki for ADAM10 in CD-1 mouse at 10 mg/kg, ip by UPLC analysis | Mus musculus | 1 | ALA4145666 | organism-based format | Scientific Literature | |
| 15. | ALA4151339 | A | Time at which brain concentration stays above in-vitro Ki for ADAM10 in CD-1 mouse at 10 mg/kg, ip by UPLC analysis | Mus musculus | 1 | ALA4145666 | organism-based format | Scientific Literature | |
| 16. | ALA4151340 | A | Time at which brain concentration stays above in-vitro Ki for ADAM10 in CD-1 mouse at 25 mg/kg, sc by UPLC analysis | Mus musculus | 1 | ALA4145666 | organism-based format | Scientific Literature | |
| 17. | ALA4151341 | A | AUC (0 to last) in CD-1 mouse brain assessed per mg tissue at 10 mg/kg, ip by UPLC analysis | Mus musculus | 1 | ALA4145666 | organism-based format | Scientific Literature | |
| 18. | ALA4151342 | A | AUC (0 to infinity) in CD-1 mouse brain assessed per mg tissue at 10 mg/kg, ip by UPLC analysis | Mus musculus | 1 | ALA4145666 | organism-based format | Scientific Literature | |
| 19. | ALA4151343 | A | Ratio of AUC (0 to infinity) in brain to plasma in CD-1 mouse at 10 mg/kg, ip by UPLC analysis | Mus musculus | 1 | ALA4145666 | organism-based format | Scientific Literature | |
| 20. | ALA4151344 | A | AUC (0 to last) in CD-1 mouse plasma at 10 mg/kg, ip by UPLC analysis | Mus musculus | 1 | ALA4145666 | organism-based format | Scientific Literature |
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