# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4132997 | Binding | Metal chelating activity assessed as inhibition of Cu2+ mediated human amyloid beta (1 to 40) aggregation at 25 uM after 2 hrs by turbidity assay | 11 | ALA4130407 | assay format | Scientific Literature | ||
2. | ALA4132998 | ADME | Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay | Homo sapiens | 11 | ALA4130407 | cell-based format | Scientific Literature | |
3. | ALA4132999 | Binding | Binding affinity to 59Fe2+ in human SK-N-MC cells labeled with 59Fe2-transferrin assessed as Fe release at 25 uM after 3 hrs by gamma scintillation counting method relative to total cellular 59Fe2+ (Rvb = 6%) | 4 | ALA4130407 | cell-based format | Scientific Literature | ||
4. | ALA4133000 | Binding | Inhibition of 59Fe2+ uptake from transferrin in human SK-N-MC cells labeled with 59Fe2-Tf assessed as 59Fe uptake level at 25 uM after 3 hrs by gamma scintillation counting method relative to untreated control | 11 | ALA4130407 | cell-based format | Scientific Literature | ||
5. | ALA4133001 | ADME | Antiproliferative activity against human SK-N-MC cells at 10 uM after 24 hrs by MTT assay relative to control | Homo sapiens | 8 | ALA4130407 | cell-based format | Scientific Literature | |
6. | ALA4133002 | Functional | Neuroprotective activity against H2O2-induced cell death in human SK-N-MC cells assessed as cell viability at 10 uM preincubated for 2 hrs followed by H2O2 addition and measured after 24 hrs by MTT assay (Rvb = 56%) | Homo sapiens | 10 | ALA4130407 | cell-based format | Scientific Literature | |
7. | ALA4133003 | Binding | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 5 mins by UV spectrophotometric analysis | Electrophorus electricus | 10 | ALA4130407 | single protein format | Scientific Literature | |
8. | ALA4133004 | Functional | Induction of autophagy in human SK-N-MC cells assessed as decrease in p62 level at 25 uM after 24 hrs by Western blot analysis | Homo sapiens | 9 | ALA4130407 | cell-based format | Scientific Literature | |
9. | ALA4133005 | Functional | Induction of autophagy in human SK-N-MC cells assessed as increase in LC3 accumulation at 25 uM after 24 hrs in presence of autophagy inhibitor Baf1 by Western blot analysis | Homo sapiens | 9 | ALA4130407 | cell-based format | Scientific Literature | |
10. | ALA4133006 | Binding | Metal chelating activity assessed as inhibition of Cu2+ mediated amyloid beta (1 to 42) (unknown origin) aggregation at 25 uM after 2 hrs by turbidity assay | 12 | ALA4130407 | assay format | Scientific Literature | ||
11. | ALA4133007 | Binding | Metal chelation activity assessed as 1:1 compound to Cu2+L complex formation in DMF:H2O (7:3) solution by EPR spectrscopy | 8 | ALA4130407 | assay format | Scientific Literature | ||
12. | ALA4133009 | Binding | Metal chelation activity assessed as 1:1 compound to Cu2+L complex formation in DMF:H2O (7:3) solution by cyclic voltametry | 6 | ALA4130407 | assay format | Scientific Literature | ||
13. | ALA4133010 | Binding | Metal chelation activity assessed as 1:2 Fe3+:L complex formation in DMF:H2O (7:3) solution by EPR spectrscopy | 5 | ALA4130407 | assay format | Scientific Literature | ||
14. | ALA4133012 | Binding | Metal chelation activity assessed as 1:2 Fe3+:L complex formation in DMF:H2O (7:3) solution by cyclic voltametry | 6 | ALA4130407 | assay format | Scientific Literature |