| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4133455 | B | Induction of abnormal HSP27 dimerization in human NCI-H460 cells at 10 uM co-treated with 17-AAG after 24 hrs by Western blot analysis | Homo sapiens | 4 | ALA4130424 | cell-based format | Scientific Literature | |
| 2. | ALA4133456 | B | Induction of abnormal HSP27 dimerization in human NCI-H460 cells at 10 uM after 12 hrs by Western blot analysis | Homo sapiens | 4 | ALA4130424 | cell-based format | Scientific Literature | |
| 3. | ALA4133457 | B | Induction of abnormal recombinant HSP27 (unknown origin) dimerization after 3 hrs by Western blot analysis | Homo sapiens | 8 | ALA4130424 | single protein format | Scientific Literature | |
| 4. | ALA4133458 | F | Induction of apoptosis in human NCI-H460 cells assessed as increase in cleaved PARP levels at 10 uM after 12 hrs by Western blot analysis | Homo sapiens | 4 | ALA4130424 | cell-based format | Scientific Literature | |
| 5. | ALA4133459 | F | Induction of apoptosis in human NCI-H460 cells assessed as increase in cleaved caspase-7 levels at 10 uM after 12 hrs by Western blot analysis | Homo sapiens | 4 | ALA4130424 | cell-based format | Scientific Literature | |
| 6. | ALA4133460 | B | Induction of abnormal HSP27 dimerization in human NCI-H460 cells assessed as potentiation of 17-AAG-induced antiproliferative activity at 10 uM after 24 hrs by EZ-CYTOX cell viability assay | Homo sapiens | 2 | ALA4130424 | cell-based format | Scientific Literature | |
| 7. | ALA4133462 | B | Induction of abnormal HSP27 dimerization in human NCI-H460 cells assessed as potentiation of 17-AAG-induced increase in cleaved PARP levels at 10 uM after 24 hrs by Western blot analysis | Homo sapiens | 5 | ALA4130424 | cell-based format | Scientific Literature | |
| 8. | ALA4133463 | B | Induction of abnormal HSP27 dimerization in human NCI-H460 cells assessed as potentiation of 17-AAG-induced increase in cleaved caspase-7 levels at 10 uM after 24 hrs by Western blot analysis | Homo sapiens | 5 | ALA4130424 | cell-based format | Scientific Literature | |
| 9. | ALA4133464 | F | Induction of apoptosis in human NCI-H460 cells assessed as necrotic cells at 10 uM after 24 hrs by Annexin V/propidium iodide double staining-based FACS analysis (Rvb = 1.29%) | Homo sapiens | 5 | ALA4130424 | cell-based format | Scientific Literature | |
| 10. | ALA4133465 | F | Induction of apoptosis in human NCI-H460 cells assessed as late apoptotic cells at 10 uM after 24 hrs by Annexin V/propidium iodide double staining-based FACS analysis (Rvb = 3.66%) | Homo sapiens | 5 | ALA4130424 | cell-based format | Scientific Literature | |
| 11. | ALA4133466 | F | Induction of apoptosis in human NCI-H460 cells assessed as early apoptotic cells at 10 uM after 24 hrs by Annexin V/propidium iodide double staining-based FACS analysis (Rvb = 3.84%) | Homo sapiens | 5 | ALA4130424 | cell-based format | Scientific Literature | |
| 12. | ALA4133470 | B | Induction of abnormal HSP27 dimerization in human NCI-H460 cells assessed as potentiation of 17-AAG-induced apoptosis by measuring late apoptotic cells at 10 uM after 24 hrs by Annexin V/propidium iodide double staining-based FACS analysis (Rvb = 7.53%) | Homo sapiens | 2 | ALA4130424 | cell-based format | Scientific Literature | |
| 13. | ALA4133471 | F | Potentiation of 17-AAG-induced antiproliferative activity in HSP27-knockdown human NCI-H460 cells at 10 uM after 24 hrs by EZ-CYTOX cell viability assay | Homo sapiens | 5 | ALA4130424 | cell-based format | Scientific Literature | |
| 14. | ALA4133472 | B | Induction of abnormal HSP27 dimerization in human NCI-H460 cells assessed as potentiation of cisplatin-induced antiproliferative activity at 10 uM after 24 hrs by EZ-CYTOX cell viability assay | Homo sapiens | 2 | ALA4130424 | cell-based format | Scientific Literature | |
| 15. | ALA4133473 | B | Induction of abnormal HSP27 dimerization in human NCI-H460 cells assessed as potentiation of cisplatin-induced increase in cleaved PARP levels at 10 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4130424 | cell-based format | Scientific Literature | |
| 16. | ALA4133474 | B | Induction of abnormal HSP27 dimerization in human NCI-H460 cells assessed as potentiation of cisplatin-induced increase in cleaved caspase-7 levels at 10 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4130424 | cell-based format | Scientific Literature | |
| 17. | ALA4133475 | F | Induction of apoptosis in human NCI-H460 cells assessed as late apoptotic cells at 10 uM after 24 hrs by Annexin V/propidium iodide double staining-based FACS analysis (Rvb = 3.92%) | Homo sapiens | 3 | ALA4130424 | cell-based format | Scientific Literature | |
| 18. | ALA4133476 | F | Induction of apoptosis in human NCI-H460 cells assessed as early apoptotic cells at 10 uM after 24 hrs by Annexin V/propidium iodide double staining-based FACS analysis (Rvb = 2.83%) | Homo sapiens | 3 | ALA4130424 | cell-based format | Scientific Literature | |
| 19. | ALA4133477 | F | Induction of apoptosis in human NCI-H460 cells assessed as necrotic cells at 10 uM after 24 hrs by Annexin V/propidium iodide double staining-based FACS analysis (Rvb = 2.92%) | Homo sapiens | 3 | ALA4130424 | cell-based format | Scientific Literature | |
| 20. | ALA4133478 | B | Induction of abnormal HSP27 dimerization in human NCI-H460 cells assessed as potentiation of cisplatin-induced apoptosis by measuring late apoptotic cells at 10 uM after 24 hrs by Annexin V/propidium iodide double staining-based FACS analysis (Rvb = 3.74%) | Homo sapiens | 2 | ALA4130424 | cell-based format | Scientific Literature |
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