# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4148151 | Binding | Inhibition of COX-2 in mouse RAW264.7 cells assessed as reduction in PGE2 production at 10 uM preincubated for 2 hrs followed by LPS stimulation measured after 24 hrs by enzyme immunoassay relative to control | Mus musculus | 8 | ALA4145523 | cell-based format | Scientific Literature | |
2. | ALA4148152 | Binding | Inhibition of COX-2 in mouse RAW264.7 cells assessed as reduction in PGE2 production at 1 uM preincubated for 2 hrs followed by LPS stimulation measured after 24 hrs by enzyme immunoassay relative to control | Mus musculus | 2 | ALA4145523 | cell-based format | Scientific Literature | |
3. | ALA4148153 | Binding | Inhibition of COX-2 in mouse RAW264.7 cells assessed as reduction in PGE2 production at 5 uM preincubated for 2 hrs followed by LPS stimulation measured after 24 hrs by enzyme immunoassay relative to control | Mus musculus | 2 | ALA4145523 | cell-based format | Scientific Literature | |
4. | ALA4148154 | Binding | Inhibition of COX-2 in mouse RAW264.7 cells assessed as reduction in PGE2 production at 20 uM preincubated for 2 hrs followed by LPS stimulation measured after 24 hrs by enzyme immunoassay relative to control | Mus musculus | 2 | ALA4145523 | cell-based format | Scientific Literature | |
5. | ALA4148155 | Binding | Inhibition of COX-2 in mouse RAW264.7 cells assessed as reduction in PGE2 production preincubated for 2 hrs followed by LPS stimulation measured after 24 hrs by enzyme immunoassay | Mus musculus | 1 | ALA4145523 | cell-based format | Scientific Literature | |
6. | ALA4148156 | Functional | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced cox-2 expression at 5 to 20 uM preincubated for 2 hrs followed by LPS challenge measured after 24 hrs by Western blot method | Mus musculus | 1 | ALA4145523 | cell-based format | Scientific Literature | |
7. | ALA4148157 | ADME | Inhibition of COX-1 in mouse RAW264.7 cells assessed as reduction in PGE2 production at 10 uM after 24 hrs by enzyme immunoassay | Mus musculus | 1 | ALA4145523 | cell-based format | Scientific Literature | |
8. | ALA4148158 | ADME | Down regulation of COX-1 expression in mouse RAW264.7 cells at 10 uM after 24 hrs by Western blot method | Mus musculus | 1 | ALA4145523 | cell-based format | Scientific Literature |