| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4143198 | F | Cytoprotective activity against H2O2-induced damage in rat PC12 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay (Rvb = 70.1 +/- 3.7%) | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 2. | ALA4143199 | F | Neuroprotective activity against H2O2-induced damage in Sprague-Dawley rat primary cortical neurons assessed as cell viability at 10 uM after 24 hrs by MTT assay (Rvb = 70 +/- 2.6%) | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA4143200 | F | Cytoprotective activity against oxygen-glucose deprivation/reoxygenation-induced damage in rat PC12 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay (Rvb = 70 +/- 5.1%) | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA4143201 | F | Neuroprotective activity against H2O2-induced damage in Sprague-Dawley rat primary cortical neurons assessed as cell viability at 1 uM after 24 hrs by MTT assay (Rvb = 70 +/- 2.6%) | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4143203 | F | Neuroprotective activity against oxygen-glucose deprivation/reoxygenation-induced damage in Sprague-Dawley rat primary cortical neurons assessed as cell viability at 10 uM after 24 hrs by MTT assay (Rvb = 100 +/- 5.1%) | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4143204 | F | Neuroprotective activity against oxygen-glucose deprivation/reoxygenation-induced damage in Sprague-Dawley rat primary cortical neurons assessed as cell viability at 1 uM after 24 hrs by MTT assay (Rvb = 100 +/- 5.1%) | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4143205 | F | Reversal of middle cerebral artery occlusion and reperfusion-induced decrease in body weight in Sprague-Dawley rat assessed as body weight at 20 mg/kg administered via oral gavage as qd for 7 days measured on day 7 post reperfusion (Rvb = 82%) | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA4143207 | F | Reversal of middle cerebral artery occlusion and reperfusion-induced death in Sprague-Dawley rat assessed as survival rate at 20 mg/kg administered via oral gavage as qd for 7 days measured on day 7 post reperfusion (Rvb = 50%) | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4143208 | F | Reversal of middle cerebral artery occlusion and reperfusion-induced death in Sprague-Dawley rat assessed as survival rate at 80 mg/kg administered via oral gavage as qd for 7 days measured on day 7 post reperfusion (Rvb = 50%) | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 10. | ALA4143209 | F | Reversal of middle cerebral artery occlusion and reperfusion-induced death in Sprague-Dawley rat assessed as survival rate at 40 mg/kg administered via oral gavage as qd for 7 days measured on day 7 post reperfusion (Rvb = 50%) | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4143211 | F | Increase in neurological function in Sprague-Dawley rat middle cerebral artery occlusion and reperfusion model assessed as decrease in behavior deficit at 20 to 80 mg/kg administered via oral gavage as qd for 7 days measured on day 7 post reperfusion by Zea Longa's test | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4143212 | F | Increase in neurological function in Sprague-Dawley rat middle cerebral artery occlusion and reperfusion model assessed as decrease in forelimb falling number at 20 to 80 mg/kg administered via oral gavage as qd for 7 days measured on day 2 to 7 during compound dosing post reperfusion by grid test | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4143213 | F | Anti-cerebral ischemia in Sprague-Dawley rat middle cerebral artery occlusion and reperfusion model assessed as decrease in brain infract volume at 20 to 40 mg/kg administered via oral gavage as qd for 7 days measured on day 7 post reperfusion by TTC staining-based assay | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4143215 | F | Antioxidant activity assessed as free radical scavenging activity at 25 mg/ml by ESR method | 2 | assay format | Scientific Literature | |||
| 15. | ALA4143216 | A | Drug uptake in Sprague-Dawley rat brain at 40 mg/kg administered via oral gavage measured at 0.083 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4143217 | A | Drug uptake in Sprague-Dawley rat brain at 40 mg/kg administered via oral gavage measured at 0.25 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4143218 | A | Drug uptake in Sprague-Dawley rat brain at 40 mg/kg administered via oral gavage measured at 0.5 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4143219 | A | Drug uptake in Sprague-Dawley rat brain at 40 mg/kg administered via oral gavage measured at 1 hr by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4143220 | A | Drug uptake in Sprague-Dawley rat brain at 40 mg/kg administered via oral gavage measured at 2 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4143221 | A | Drug uptake in Sprague-Dawley rat brain at 40 mg/kg administered via oral gavage measured at 4 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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