# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4142733 | F | Analgesic activity in CFA-induced paw inflammation Wistar rat model assessed as increase in paw withdrawal latency at 10 mg/kg, iv administered at 24 hrs post CFA injection measured at 30 mins post compound administration | Rattus norvegicus | 2 | ALA4138200 | organism-based format | Scientific Literature | |
2. | ALA4142742 | B | Positive allosteric modulation of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as acetyl choline-evoked currents at 10 uM at -80 mV holding potential prtreated for 2 mins followed by co-treatment with acetyl choline by electrophysiology method relative to acetyl choline | Homo sapiens | 7 | ALA4138200 | cell-based format | Scientific Literature | |
3. | ALA4142743 | F | Analgesic activity in CFA-induced paw inflammation Wistar rat model assessed as increase in paw withdrawal latency at 10 mg/kg, iv administered at 24 hrs post CFA injection measured at 1 hr post compound administration | Rattus norvegicus | 2 | ALA4138200 | organism-based format | Scientific Literature | |
4. | ALA4142744 | F | Analgesic activity in CFA-induced paw inflammation Wistar rat model assessed as increase in paw withdrawal latency at 10 mg/kg, iv administered at 24 hrs post CFA injection measured at 3 hrs post compound administration | Rattus norvegicus | 1 | ALA4138200 | organism-based format | Scientific Literature | |
5. | ALA4142745 | P | Prodrug activation in PBS/5% DMSO solution assessed as 1-(2,5-dihydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one formation at 25 degC after 5 hrs by HPLC analysis | 2 | ALA4138200 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4142746 | A | Prodrug conversion assessed as human recombinant CD26-mediated 1-(2,5-dihydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one formation after 15 min by HPLC analysis | Homo sapiens | 1 | ALA4138200 | single protein format | Scientific Literature | |
7. | ALA4142747 | A | Prodrug conversion assessed as human recombinant CD26-mediated 1-(2,5-dihydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one formation after 1 hr by HPLC analysis | Homo sapiens | 1 | ALA4138200 | single protein format | Scientific Literature | |
8. | ALA4142748 | A | Prodrug conversion in 20% human serum assessed as CD26-mediated 1-(2,5-dihydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one formation after 60 mins by HPLC analysis | Homo sapiens | 1 | ALA4138200 | single protein format | Scientific Literature | |
9. | ALA4142749 | A | Prodrug conversion in 20% bovine serum assessed as CD26-mediated 1-(2,5-dihydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one formation after 6 hrs by HPLC analysis | Bos taurus | 1 | ALA4138200 | single protein format | Scientific Literature |