| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4152830 | B | Binding affinity to wild-type human partial length ALK (I1088 to E1409 residues) expressed in mammalian expression system by KINOMEscan assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 2. | ALA4152840 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated NPM-ALK fusion protein degradation in human SU-DHL1 cells assessed as reduction in NPM-ALK fusion protein levels at 30 nM after 16 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 3. | ALA4152841 | B | Inhibition of ALK autophosphorylation at Y1507 residue in human SU-DHL1 cells at 30 nM after 16 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA4152842 | B | Inhibition of ALK in human SU-DHL1 cells assessed as reduction in STAT3 phosphorylation at Y705 residue at 30 nM after 16 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA4152844 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human NCI-H2228 cells assessed as reduction in EML4-ALK fusion protein levels at 100 nM after 16 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 6. | ALA4152860 | F | Growth inhibition of human SU-DHL1 cells after 3 days by luminescence-based CellTiter-Glo assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 7. | ALA4152861 | F | Growth inhibition of human NCI-H2228 cells after 3 days by luminescence-based CellTiter-Glo assay | Homo sapiens | 5 | cell-based format | Scientific Literature |
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