| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4146975 | B | Displacement of [125I]D-Trp6-LHRH from human GnRH receptor expressed in CHO-K1 cells after 1 hr by microbeta scintillation counting method | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 2. | ALA4146976 | F | Antagonist activity at human GnRH receptor expressed in HEK293 cells co-expressing pGL4-NFATpromoter AP-1-luc assessed as inhibition of GnRH-induced NFAT promoter activation preincubated for 1 hr followed by GnRH addition measured after 6 hrs by luciferase reporter gene assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 3. | ALA4146978 | A | Inhibition of recombinant human CYP3A4 expressed in baculovirus infected insect cells at 1 uM using BOMR substrate after 30 mins by fluorescence assay relative to control | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 4. | ALA4146979 | A | Inhibition of recombinant human CYP3A4 expressed in baculovirus infected insect cells at 10 uM using BOMR substrate after 30 mins by fluorescence assay relative to control | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 5. | ALA4146980 | B | Displacement of [125I]D-Trp6-LHRH from monkey GnRH receptor expressed in HEK293 cells after 1 hr by microbeta scintillation counting method | Macaca mulatta | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA4146981 | F | Antagonist activity at rat GnRH receptor expressed in HEK293 cells co-expressing pGL4-NFATpromoter AP-1-luc assessed as inhibition of GnRH-induced NFAT promoter activation preincubated for 1 hr followed by GnRH addition measured after 6 hrs by luciferase reporter gene assay | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA4146982 | B | Selectivity ratio of IC50 for displacement of [125I]D-Trp6-LHRH from monkey GnRH receptor expressed in HEK293 cells to IC50 for displacement of [125I]D-Trp6-LHRH from human GnRH receptor expressed in CHO-K1 cells | 1 | cell-based format | Scientific Literature | |||
| 8. | ALA4146983 | B | Selectivity ratio of IC50 for antagonist activity at rat GnRH receptor expressed in HEK293 cells co-expressing pGL4-NFATpromoter AP-1-luc to IC50 for atagonist activity at human GnRH receptor expressed in HEK293 cells co-expressing pGL4-NFATpromoter AP-1-luc | 1 | cell-based format | Scientific Literature |
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