#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4140795	B	Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) using single stranded poly(U) RNA as substrate after 40 mins by ADP-Glo luminescence assay	Homo sapiens	3	ALA4138137	assay format	Scientific Literature
2.	ALA4140796	B	Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) using single stranded poly(U) RNA as substrate after 30 mins by ADP-Glo luminescence assay	Homo sapiens	17	ALA4138137	assay format	Scientific Literature
3.	ALA4140797	P	Solubility of the compound at pH 6.8		9	ALA4138137	small-molecule physicochemical format	Scientific Literature
4.	ALA4140798	A	Metabolic stability in mouse microsomes	Mus musculus	9	ALA4138137	microsome format	Scientific Literature
5.	ALA4140799	A	AUC (0 to 8 hrs) in ICR mouse at 1 mg/kg, po administered as cassette dose	Mus musculus	7	ALA4138137	organism-based format	Scientific Literature
6.	ALA4140800	A	Oral bioavailability in ICR mouse at 1 mg/kg administered as cassette dose	Mus musculus	7	ALA4138137	organism-based format	Scientific Literature
7.	ALA4140801	B	Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A2 RNA dependent ATPase activity using single stranded poly(U) RNA as substrate after 40 mins by ADP-Glo luminescence assay	Homo sapiens	3	ALA4138137	single protein format	Scientific Literature
8.	ALA4140802	B	Inhibition of human recombinant N-terminal full length His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cells using single stranded poly(U) RNA as substrate after 30 mins by ADP-Glo luminescence assay	Homo sapiens	3	ALA4138137	cell-based format	Scientific Literature
9.	ALA4140803	B	Inhibition of human recombinant N-terminal full length FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cells using single stranded poly(U) RNA as substrate after 30 mins by ADP-Glo luminescence assay	Homo sapiens	3	ALA4138137	cell-based format	Scientific Literature
10.	ALA4140804	B	Inhibition of NMD in human HCT116 cells assessed as upregulation of SC35 1.6 kb mRNA expression level at 1 uM after 6 hrs by qPCR analysis relative to control	Homo sapiens	2	ALA4138137	cell-based format	Scientific Literature
11.	ALA4140805	B	Inhibition of NMD in human HCT116 cells assessed as upregulation of SC35 1.6 kb mRNA expression level at 3 uM after 6 hrs by qPCR analysis relative to control	Homo sapiens	2	ALA4138137	cell-based format	Scientific Literature
12.	ALA4140806	B	Inhibition of NMD in human HCT116 cells assessed as upregulation of SC35 1.6 kb mRNA expression level at 10 uM after 6 hrs by qPCR analysis relative to control	Homo sapiens	2	ALA4138137	cell-based format	Scientific Literature
13.	ALA4140807	F	Growth inhibition of human HCT116 cells after 3 days by CellTiter-Glo luminescence assay	Homo sapiens	3	ALA4138137	cell-based format	Scientific Literature
14.	ALA4140811	F	In vivo inhibition of NMD in BALB/cA Jc1 nude mouse xenografted with human HCT116 cells assessed as upregulation of SC35 1.6 kb mRNA expression level in tumor at 100 mg/kg, po administered as single dose measured after 4 hrs by qPCR analysis relative to control	Mus musculus	2	ALA4138137	organism-based format	Scientific Literature
15.	ALA4140812	F	In vivo inhibition of NMD in BALB/cA Jc1 nude mouse xenografted with human HCT116 cells assessed as upregulation of SC35 1.6 kb mRNA expression level in tumor at 100 mg/kg, po administered as single dose measured after 8 hrs by qPCR analysis relative to control	Mus musculus	2	ALA4138137	organism-based format	Scientific Literature
16.	ALA4140813	F	In vivo inhibition of NMD in BALB/cA Jc1 nude mouse xenografted with human HCT116 cells assessed as upregulation of SC35 1.6 kb mRNA expression level in tumor at 100 mg/kg, po administered as single dose measured after 24 hrs by qPCR analysis relative to control	Mus musculus	2	ALA4138137	organism-based format	Scientific Literature
17.	ALA4140814	F	Antitumor activity against human HCT116 cells xenografted in BALB/cA Jc1 nude mouse assessed as reduction in tumor volume at 100 mg/kg, po bid administered for 14 days measured twice per week relative to control	Homo sapiens	2	ALA4138137	organism-based format	Scientific Literature
18.	ALA4140815	T	Toxicity in BALB/cA Jc1 nude mouse xenografted with human HCT116 cells assessed as reduction in body weight at 100 mg/kg, po bid administered for 14 days measured twice per week	Mus musculus	2	ALA4138137	organism-based format	Scientific Literature
19.	ALA4140816	A	Substrate activity at MDR1 (unknown origin) assessed as efflux ratio of permeability	Homo sapiens	5	ALA4138137	single protein format	Scientific Literature