| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4137168 | P | Prodrug activation in phosphate buffer at pH 7.3 assessed as half life for T-1105-RDP formation at 450 uM after 24 to 120 hrs by RP-HPLC-UV analysis | 1 | ALA4130627 | small-molecule physicochemical format | Scientific Literature | ||
| 2. | ALA4137169 | P | Drug metabolism in phosphate buffer at pH 7.3 assessed as half life for 4-((((((2R,3S,4R,5R)-5-(3-carbamoyl-2-oxopyrazin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryloxy)(hydroxy)phosphoryloxy)methyl)phenyl decanoate formation at 450 uM after 24 to 120 hrs by RP-HPLC-UV analysis | 1 | ALA4130627 | small-molecule physicochemical format | Scientific Literature | ||
| 3. | ALA4137170 | A | Prodrug activation assessed as pig liver esterase mediated T-1105-RMP formation at 450 uM up to 150 mins by RP-HPLC-UV analysis | Sus scrofa | 1 | ALA4130627 | assay format | Scientific Literature | |
| 4. | ALA4137171 | A | Prodrug activation assessed as pig liver esterase mediated metabolite formation at 450 uM up to 150 mins by RP-HPLC-UV analysis | Sus scrofa | 1 | ALA4130627 | assay format | Scientific Literature | |
| 5. | ALA4137172 | A | Prodrug activation assessed as pig liver esterase mediated T-1105-RDP formation at 450 uM after 30 mins by RP-HPLC-UV analysis | Sus scrofa | 1 | ALA4130627 | assay format | Scientific Literature | |
| 6. | ALA4137173 | A | Prodrug activation assessed as pig liver esterase mediated T-1105-RDP formation at 450 uM after 150 mins by RP-HPLC-UV analysis | Sus scrofa | 1 | ALA4130627 | assay format | Scientific Literature | |
| 7. | ALA4137174 | A | Drug metabolism assessed as pig liver esterase mediated 4-((((((2R,3S,4R,5R)-5-(3-carbamoyl-2-oxopyrazin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryloxy)(hydroxy)phosphoryloxy)methyl)phenyl decanoate formation at 450 uM after 150 mins by RP-HPLC-UV analysis | Sus scrofa | 1 | ALA4130627 | assay format | Scientific Literature | |
| 8. | ALA4137179 | P | Prodrug activation in phosphate buffer at pH 7.3 assessed as half life for T-1105-RMP formation at 450 uM after 24 to 120 hrs by RP-HPLC-UV analysis | 1 | ALA4130627 | small-molecule physicochemical format | Scientific Literature | ||
| 9. | ALA4137186 | F | Antiviral activity against Influenza virus A/X-31 infected in MDCK cells assessed as reduction in viral replication at 3 days post infection by microscopic analysis | Influenza A virus (A/X-31(H3N2)) | 13 | ALA4130627 | organism-based format | Scientific Literature | |
| 10. | ALA4137187 | F | Antiviral activity against Influenza virus A/X-31 infected in MDCK cells assessed as reduction in viral replication at 3 days post infection by formazan-based MTS assay | Influenza A virus (A/X-31(H3N2)) | 13 | ALA4130627 | organism-based format | Scientific Literature | |
| 11. | ALA4137188 | F | Antiviral activity against Influenza virus B/Ned/537/05 infected in MDCK cells assessed as reduction in viral replication at 3 days post infection by microscopic analysis | Influenza B virus | 13 | ALA4130627 | organism-based format | Scientific Literature | |
| 12. | ALA4137189 | F | Antiviral activity against Influenza virus B/Ned/537/05 infected in MDCK cells assessed as reduction in viral replication at 3 days post infection by formazan-based MTS assay | Influenza B virus | 13 | ALA4130627 | organism-based format | Scientific Literature | |
| 13. | ALA4137190 | A | Cytotoxicity against MDCK cells assessed as change in cell morphology after 3 days by microscopic analysis | Canis lupus familiaris | 13 | ALA4130627 | cell-based format | Scientific Literature | |
| 14. | ALA4137191 | A | Cytotoxicity against MDCK cells assessed as reduction in cell viability after 3 days by formazan-based MTS assay | Canis lupus familiaris | 13 | ALA4130627 | cell-based format | Scientific Literature | |
| 15. | ALA4137192 | F | Antiviral activity against Influenza virus A/X-31 infected in HGPRT deficient 6-thioguanine-resistant MDCK cells assessed as reduction in viral replication at 3 days post infection by microscopic analysis | Influenza A virus (A/X-31(H3N2)) | 13 | ALA4130627 | organism-based format | Scientific Literature | |
| 16. | ALA4137193 | F | Antiviral activity against Influenza virus A/X-31 infected in HGPRT deficient 6-thioguanine-resistant MDCK cells assessed as reduction in viral replication at 3 days post infection by formazan-based MTS assay | Influenza A virus (A/X-31(H3N2)) | 13 | ALA4130627 | organism-based format | Scientific Literature | |
| 17. | ALA4137194 | F | Antiviral activity against Influenza virus B/Ned/537/05 infected in HGPRT deficient 6-thioguanine-resistant MDCK cells assessed as reduction in viral replication at 3 days post infection by microscopic analysis | Influenza B virus | 13 | ALA4130627 | organism-based format | Scientific Literature | |
| 18. | ALA4137195 | F | Antiviral activity against Influenza virus B/Ned/537/05 infected in HGPRT deficient 6-thioguanine-resistant MDCK cells assessed as reduction in viral replication at 3 days post infection by formazan-based MTS assay | Influenza B virus | 13 | ALA4130627 | organism-based format | Scientific Literature | |
| 19. | ALA4137196 | A | Cytotoxicity against HGPRT deficient 6-thioguanine-resistant MDCK cells assessed as change in cell morphology after 3 days by microscopic analysis | Canis lupus familiaris | 13 | ALA4130627 | cell-based format | Scientific Literature | |
| 20. | ALA4137197 | A | Cytotoxicity against HGPRT deficient 6-thioguanine-resistant MDCK cells assessed as reduction in cell viability after 3 days by formazan-based MTS assay | Canis lupus familiaris | 13 | ALA4130627 | cell-based format | Scientific Literature |
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