# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4132839 | Binding | Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of leucovorin by MTT assay | Homo sapiens | 8 | ALA4130394 | cell-based format | Scientific Literature | |
2. | ALA4132840 | Functional | Antiproliferative activity against human SW620 cells in folate free medium after 72 hrs in presence of leucovorin by MTT assay | Homo sapiens | 8 | ALA4130394 | cell-based format | Scientific Literature | |
3. | ALA4132841 | Functional | Antiproliferative activity against human MCF7 cells in folate free medium after 72 hrs in presence of leucovorin by MTT assay | Homo sapiens | 8 | ALA4130394 | cell-based format | Scientific Literature | |
4. | ALA4132844 | Functional | Inhibition of colony formation in human KB cells at 100 nM after 10 to 14 days by methylene blue staining based assay relative to control | Homo sapiens | 2 | ALA4130394 | cell-based format | Scientific Literature | |
5. | ALA4132845 | Binding | Inhibition of thymidylate synthase in human KB cells assessed as reduction in cell proliferation at 1 to 10 nM after 72 hrs in presence of excess of thymidine by MTT assay | Homo sapiens | 2 | ALA4130394 | cell-based format | Scientific Literature | |
6. | ALA4132846 | Binding | Inhibition of AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation at 1 to 10 nM after 72 hrs in presence of excess of adenosine by MTT assay | Homo sapiens | 2 | ALA4130394 | cell-based format | Scientific Literature | |
7. | ALA4132847 | Binding | Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation at 1 to 10 nM after 72 hrs in presence of excess of thymidine and adenosine by MTT assay | Homo sapiens | 2 | ALA4130394 | cell-based format | Scientific Literature | |
8. | ALA4132848 | Binding | Inhibition of AICARFTase in human KB cells assessed as reduction in cell proliferation at 1 to 10 nM after 72 hrs in presence of excess of AICA by MTT assay | Homo sapiens | 1 | ALA4130394 | cell-based format | Scientific Literature | |
9. | ALA4132849 | Binding | Inhibition of TS/AICARFTase in human KB cells assessed as reduction in cell proliferation at 1 to 10 nM after 72 hrs in presence of excess of thymidine and AICA by MTT assay | Homo sapiens | 1 | ALA4130394 | cell-based format | Scientific Literature | |
10. | ALA4132861 | Functional | Cell cycle arrest in human KB cells assessed as accumulation at S phase at 1 uM after 96 hrs by propidium iodide staining based flow cytometry (Rvb = 35.66%) | Homo sapiens | 2 | ALA4130394 | cell-based format | Scientific Literature | |
11. | ALA4132862 | Functional | Cell cycle arrest in human KB cells assessed as accumulation at G2 phase at 1 uM after 96 hrs by propidium iodide staining based flow cytometry (Rvb = 9.59%) | Homo sapiens | 2 | ALA4130394 | cell-based format | Scientific Literature | |
12. | ALA4132863 | Functional | Cell cycle arrest in human KB cells assessed as accumulation at G1 phase at 1 uM after 96 hrs by propidium iodide staining based flow cytometry (Rvb = 54.75%) | Homo sapiens | 2 | ALA4130394 | cell-based format | Scientific Literature | |
13. | ALA4132868 | Functional | Induction of apoptosis in human KB cells assessed as live cells at 1 uM after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 74.6%) | Homo sapiens | 2 | ALA4130394 | cell-based format | Scientific Literature | |
14. | ALA4132869 | Functional | Induction of apoptosis in human KB cells assessed as early apoptotic cells at 1 uM after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 16.9%) | Homo sapiens | 2 | ALA4130394 | cell-based format | Scientific Literature | |
15. | ALA4132870 | Functional | Induction of apoptosis in human KB cells assessed as late apoptotic cells at 1 uM after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 5.5%) | Homo sapiens | 2 | ALA4130394 | cell-based format | Scientific Literature | |
16. | ALA4132871 | Functional | Induction of apoptosis in human KB cells assessed as necrotic cells at 1 uM after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 3%) | Homo sapiens | 2 | ALA4130394 | cell-based format | Scientific Literature |