| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4158376 | B | Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assay | Homo sapiens | 54 | ALA4152377 | single protein format | Scientific Literature | |
| 2. | ALA4158377 | B | Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assay | Homo sapiens | 32 | ALA4152377 | cell-based format | Scientific Literature | |
| 3. | ALA4312562 | B | Inhibition of N-(3-Chlorophenyl-4,6-t2)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine binding to his-tagged HIF-2alpha PAS-B domain (unknown origin) measured after 1 hr by scintillation proximity assay | Homo sapiens | 10 | ALA4311943 | single protein format | Scientific Literature | |
| 4. | ALA4312563 | B | Inhibition of HIF-2alpha (unknown origin) expressed in human 786-O cells measured after 24 hrs by one-glo luciferase reporter gene assay | Homo sapiens | 8 | ALA4311943 | cell-based format | Scientific Literature | |
| 5. | ALA4312565 | A | Substrate activity at recombinant human UGT2B17 expressed in baculovirus infected insect cell membranes assessed as enzyme-mediated glucuronidation by measuring Vmax per mg protein at 50 uM preincubated for 5 mins followed by UDPGA addition and measured after 60 mins by LC-MS/MS analysis | Homo sapiens | 7 | ALA4311943 | assay format | Scientific Literature | |
| 6. | ALA4312566 | A | Substrate activity at recombinant human UGT2B17 expressed in baculovirus infected insect cell membranes assessed as enzyme-mediated glucuronidation by measuring Km at 50 uM preincubated for 5 mins followed by UDPGA addition and measured after 60 mins by LC-MS/MS analysis | Homo sapiens | 7 | ALA4311943 | assay format | Scientific Literature | |
| 7. | ALA4312567 | A | Substrate activity at UGT2B17 in human intestinal microsomes assessed as enzyme-mediated glucuronidation by measuring Vmax per mg protein at 2 to 1000 uM preincubated for 5 mins followed by UDPGA addition and measured after 60 mins by LC-MS/MS analysis | Homo sapiens | 7 | ALA4311943 | microsome format | Scientific Literature | |
| 8. | ALA4312568 | A | Substrate activity at UGT2B17 in human intestinal microsomes assessed as enzyme-mediated glucuronidation by measuring Km at 2 to 1000 uM preincubated for 5 mins followed by UDPGA addition and measured after 60 mins by LC-MS/MS analysis | Homo sapiens | 7 | ALA4311943 | microsome format | Scientific Literature |
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