| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4151113 | B | Inhibition of recombinant human sPLA2-10 expressed in Escherichia coli BL21(DE3) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substrate addition and measured after 60 mins | Homo sapiens | 32 | assay format | Scientific Literature | ||
| 2. | ALA4151114 | B | Inhibition of recombinant human sPLA2-10 expressed in Escherichia coli BL21(DE3) using HDL as substrate pretreated for 20 mins followed by substrate addition and measured after 60 mins | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 3. | ALA4151115 | B | Inhibition of recombinant human sPLA2-2A expressed in Escherichia coli BL21(DE3) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substrate addition and measured after 60 mins | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 4. | ALA4151117 | B | Inhibition of recombinant human sPLA2-5 expressed in Escherichia coli BL21(DE3) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substrate addition and measured after 60 mins | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 5. | ALA4151119 | B | Inhibition of mouse sPLA2-10 using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substrate addition and measured after 60 mins | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 6. | ALA4151120 | B | Selectivity ratio of IC50 for recombinant human sPLA2-2A expressed in Escherichia coli BL21(DE3) to IC50 for recombinant human sPLA2-10 expressed in Escherichia coli BL21(DE3) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 7. | ALA4151121 | B | Selectivity ratio of IC50 for recombinant human sPLA2-5 expressed in Escherichia coli BL21(DE3) to IC50 for recombinant human sPLA2-10 expressed in Escherichia coli BL21(DE3) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA4151122 | P | Aqueous solubility of the compound in DMSO/HBSS solution measured after 24 hrs by LC-UV/MS analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA4151123 | A | Permeability across apical to basolateral side in human Caco2 cells at 10 uM measured over 120 mins by UPLC/MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4151124 | A | Intrinsic clearance in human hepatocytes assessed per million cells at 1 uM measured after 2 to 60 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4151125 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv by LC/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4151126 | A | AUC in Sprague-Dawley rat at 1 mg/kg, iv by LC/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4151127 | A | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv by LC/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4151128 | A | AUC in Sprague-Dawley rat at 4 mg/kg, po administered via gavage by LC/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4151129 | A | Oral bioavailability in Sprague-Dawley rat at 4 mg/kg administered via gavage by LC/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4151130 | A | Clearance in Beagle dog at 1 mg/kg, iv by LC/MS analysis | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4151131 | A | AUC in Beagle dog at 1 mg/kg, iv by LC/MS analysis | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4151132 | A | Volume of distribution at steady state in Beagle dog at 1 mg/kg, iv by LC/MS analysis | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4199509 | B | Inhibition of sPLA2-10 (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substrate addition and measured after 60 mins by NEFA based assay | Homo sapiens | 18 | single protein format | Scientific Literature | ||
| 20. | ALA4199510 | B | Inhibition of sPLA2-2A (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substrate addition and measured after 60 mins by NEFA based assay | Homo sapiens | 16 | single protein format | Scientific Literature |
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