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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4150992 B Inhibition of FAM-labeled ZBA248 binding to recombinant human BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 Escherichia coli DE3 cells after 30 mins by fluorescence polarization assay Homo sapiens 31 ALA4145654 cell-based format Scientific Literature 2. ALA4185403 F Growth inhibition of human MOLM13 cells after 4 days by WST-8 assay Homo sapiens 34 ALA4184143 cell-based format Scientific Literature 3. ALA4185404 F Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay Homo sapiens 34 ALA4184143 cell-based format Scientific Literature 4. ALA4185405 B Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 2 (333 to 460 residues) expressed in Rosetta2 DE3 cells after 30 mins by Flourescence polarization assay Homo sapiens 37 ALA4184143 cell-based format Scientific Literature 5. ALA4185406 F Cytotoxicity against human HCC1395 cells assessed as cell growth inhibition after 4 days by WST-8 assay Homo sapiens 1 ALA4184143 cell-based format Scientific Literature 6. ALA4185407 F Cytotoxicity against human SUM149PT cells assessed as cell growth inhibition after 4 days by WST-8 assay Homo sapiens 1 ALA4184143 cell-based format Scientific Literature 7. ALA4185408 B Inhibition of human PLK4 (M1 to S273 residues) expressed in mammalian expression system Homo sapiens 1 ALA4184143 assay format Scientific Literature 8. ALA4185409 T Toxicity in SCID mouse implanted with human MDA-MB-231 cells assessed as weight loss at 40 mg/kg, po qd measured 2 to 3 times weekly during treatment and weekly post dose Mus musculus 1 ALA4184143 organism-based format Scientific Literature 9. ALA4185410 B Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 DE3 cells after 30 mins by Flourescence polarization assay Homo sapiens 37 ALA4184143 cell-based format Scientific Literature 10. ALA4185412 A Half life in Sprague-Dawley rat at 25 mg/kg, po by LC/MS method Rattus norvegicus 2 ALA4184143 organism-based format Scientific Literature 11. ALA4185413 A Cmax in Sprague-Dawley rat at 25 mg/kg, po by LC/MS method Rattus norvegicus 2 ALA4184143 organism-based format Scientific Literature 12. ALA4185414 A AUC (0 to t) in Sprague-Dawley rat at 25 mg/kg, po by LC/MS method Rattus norvegicus 2 ALA4184143 organism-based format Scientific Literature 13. ALA4185415 A Half life in Sprague-Dawley rat at 5 mg/kg, iv by LC/MS method Rattus norvegicus 1 ALA4184143 organism-based format Scientific Literature 14. ALA4185416 A Clearance in Sprague-Dawley rat at 25 mg/kg, po by LC/MS method Rattus norvegicus 2 ALA4184143 organism-based format Scientific Literature 15. ALA4185417 A Oral bioavailability in Sprague-Dawley rat at 25 mg/kg by LC/MS method Rattus norvegicus 1 ALA4184143 organism-based format Scientific Literature 16. ALA4185418 A AUC (0 to t) in Sprague-Dawley rat at 5 mg/kg, iv by LC/MS method Rattus norvegicus 1 ALA4184143 organism-based format Scientific Literature 17. ALA4185419 A Volume of distribution at steady state in Sprague-Dawley rat at 5 mg/kg, iv by LC/MS method Rattus norvegicus 1 ALA4184143 organism-based format Scientific Literature 18. ALA4185420 A Clearance in Sprague-Dawley rat at 5 mg/kg, iv by LC/MS method Rattus norvegicus 1 ALA4184143 organism-based format Scientific Literature 19. ALA4185421 A Half life in SCID mouse at 5 mg/kg, iv by LC/MS method Mus musculus 1 ALA4184143 organism-based format Scientific Literature 20. ALA4185422 A AUC (0 to t) in SCID mouse at 5 mg/kg, iv by LC/MS method Mus musculus 1 ALA4184143 organism-based format Scientific Literature