| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4150992 | B | Inhibition of FAM-labeled ZBA248 binding to recombinant human BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 Escherichia coli DE3 cells after 30 mins by fluorescence polarization assay | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 2. | ALA4185403 | F | Growth inhibition of human MOLM13 cells after 4 days by WST-8 assay | Homo sapiens | 34 | cell-based format | Scientific Literature | ||
| 3. | ALA4185404 | F | Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay | Homo sapiens | 34 | cell-based format | Scientific Literature | ||
| 4. | ALA4185405 | B | Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 2 (333 to 460 residues) expressed in Rosetta2 DE3 cells after 30 mins by Flourescence polarization assay | Homo sapiens | 37 | cell-based format | Scientific Literature | ||
| 5. | ALA4185406 | F | Cytotoxicity against human HCC1395 cells assessed as cell growth inhibition after 4 days by WST-8 assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4185407 | F | Cytotoxicity against human SUM149PT cells assessed as cell growth inhibition after 4 days by WST-8 assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4185408 | B | Inhibition of human PLK4 (M1 to S273 residues) expressed in mammalian expression system | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA4185409 | T | Toxicity in SCID mouse implanted with human MDA-MB-231 cells assessed as weight loss at 40 mg/kg, po qd measured 2 to 3 times weekly during treatment and weekly post dose | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4185410 | B | Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 DE3 cells after 30 mins by Flourescence polarization assay | Homo sapiens | 37 | cell-based format | Scientific Literature | ||
| 10. | ALA4185412 | A | Half life in Sprague-Dawley rat at 25 mg/kg, po by LC/MS method | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 11. | ALA4185413 | A | Cmax in Sprague-Dawley rat at 25 mg/kg, po by LC/MS method | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 12. | ALA4185414 | A | AUC (0 to t) in Sprague-Dawley rat at 25 mg/kg, po by LC/MS method | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 13. | ALA4185415 | A | Half life in Sprague-Dawley rat at 5 mg/kg, iv by LC/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4185416 | A | Clearance in Sprague-Dawley rat at 25 mg/kg, po by LC/MS method | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 15. | ALA4185417 | A | Oral bioavailability in Sprague-Dawley rat at 25 mg/kg by LC/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4185418 | A | AUC (0 to t) in Sprague-Dawley rat at 5 mg/kg, iv by LC/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4185419 | A | Volume of distribution at steady state in Sprague-Dawley rat at 5 mg/kg, iv by LC/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4185420 | A | Clearance in Sprague-Dawley rat at 5 mg/kg, iv by LC/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4185421 | A | Half life in SCID mouse at 5 mg/kg, iv by LC/MS method | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4185422 | A | AUC (0 to t) in SCID mouse at 5 mg/kg, iv by LC/MS method | Mus musculus | 1 | organism-based format | Scientific Literature |
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