# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4143352 | Binding | Activation of Keap1/Nrf2 in human MCF7 cells assessed as Nrf2 stabilization incubated overnight by luciferase reporter gene based luminescence assay | Homo sapiens | 1 | ALA4138226 | cell-based format | Scientific Literature | |
2. | ALA4143353 | Functional | Antiinflammatory activity in hypersensitivity CD1 mouse ear edema model assessed as PMA-induced ear edema at 3 umol/ear applied topically pretreated for 10 mins followed by PMA application measured after 6 hrs (Rvb = 32.5 +/- 7.5%) | Mus musculus | 1 | ALA4138226 | organism-based format | Scientific Literature | |
3. | ALA4143354 | Functional | Antiinflammatory activity in hypersensitivity CD1 mouse ear edema model assessed as PMA-induced ear edema at 1 umol/ear applied topically pretreated for 10 mins followed by PMA application measured after 6 hrs (Rvb = 32.5 +/- 7.5%) | Mus musculus | 1 | ALA4138226 | organism-based format | Scientific Literature | |
4. | ALA4143355 | Functional | Antiinflammatory activity in hypersensitivity CD1 mouse ear edema model assessed as PMA-induced ear edema at 0.3 umol/ear applied topically pretreated for 10 mins followed by PMA application measured after 6 hrs (Rvb = 32.5 +/- 7.5%) | Mus musculus | 1 | ALA4138226 | organism-based format | Scientific Literature | |
5. | ALA4143356 | Functional | Antiinflammatory activity in hypersensitivity CD1 mouse ear edema model assessed as PMA-induced ear edema at 0.1 umol/ear applied topically pretreated for 10 mins followed by PMA application measured after 6 hrs (Rvb = 32.5 +/- 7.5%) | Mus musculus | 1 | ALA4138226 | organism-based format | Scientific Literature | |
6. | ALA4143357 | Binding | Activation of Keap1/Nrf2 in mouse LPS-induced RAW264.7 cells assessed as increase in Srxn1 expression level at 4 to 12 uM pretreated for 1 hr followed by LPS addition measured after 30 to 180 mins | Mus musculus | 1 | ALA4138226 | cell-based format | Scientific Literature | |
7. | ALA4143358 | Binding | Activation of Keap1/Nrf2 in mouse LPS-induced RAW264.7 cells assessed as increase in Hmox1 expression level at 12 uM pretreated for 1 hr followed by LPS addition measured after 30 to 180 mins | Mus musculus | 1 | ALA4138226 | cell-based format | Scientific Literature | |
8. | ALA4143359 | Binding | Activation of Keap1/Nrf2 in mouse LPS-induced RAW264.7 cells assessed as downregulation of Socs3 expression level at 4 to 12 uM pretreated for 1 hr followed by LPS addition measured after 30 mins | Mus musculus | 1 | ALA4138226 | cell-based format | Scientific Literature | |
9. | ALA4143360 | Binding | Activation of Keap1/Nrf2 in mouse LPS-induced RAW264.7 cells assessed as downregulation of Rasgef1 expression level at 4 to 12 uM pretreated for 1 hr followed by LPS addition measured after 30 mins | Mus musculus | 1 | ALA4138226 | cell-based format | Scientific Literature | |
10. | ALA4143361 | Binding | Activation of Keap1/Nrf2 in mouse LPS-induced RAW264.7 cells assessed as increase in Txrdn1 expression level at 4 to 12 uM pretreated for 1 hr followed by LPS addition measured after 30 to 180 mins | Mus musculus | 1 | ALA4138226 | cell-based format | Scientific Literature | |
11. | ALA4143362 | Binding | Activation of Keap1/Nrf2 in mouse LPS-induced RAW264.7 cells assessed as increase in Prdx1 expression level at 4 to 12 uM pretreated for 1 hr followed by LPS addition measured after 30 to 180 mins | Mus musculus | 1 | ALA4138226 | cell-based format | Scientific Literature | |
12. | ALA4143363 | Binding | Activation of Keap1/Nrf2 in mouse LPS-induced RAW264.7 cells assessed as increase in Sqstm1 expression level at 4 to 12 uM pretreated for 1 hr followed by LPS addition measured after 30 to 180 mins | Mus musculus | 1 | ALA4138226 | cell-based format | Scientific Literature | |
13. | ALA4143364 | Binding | Activation of Keap1/Nrf2 in mouse LPS-induced RAW264.7 cells assessed as increase in Gclm expression level at 4 to 12 uM pretreated for 1 hr followed by LPS addition measured after 30 to 180 mins | Mus musculus | 1 | ALA4138226 | cell-based format | Scientific Literature | |
14. | ALA4143365 | Binding | Activation of Keap1/Nrf2 in mouse LPS-induced RAW264.7 cells assessed as increase in Slc7a11 expression level at 4 to 12 uM pretreated for 1 hr followed by LPS addition measured after 30 to 180 mins | Mus musculus | 1 | ALA4138226 | cell-based format | Scientific Literature | |
15. | ALA4143366 | Binding | Activation of Keap1/Nrf2 in mouse LPS-induced RAW264.7 cells assessed as increase in Akr1b8 expression level at 4 to 12 uM pretreated for 1 hr followed by LPS addition measured after 30 to 180 mins | Mus musculus | 1 | ALA4138226 | cell-based format | Scientific Literature | |
16. | ALA4143367 | Binding | Activation of Keap1/Nrf2 in mouse LPS-induced RAW264.7 cells assessed as change in Procr expression level at 4 to 12 uM pretreated for 1 hr followed by LPS addition measured after 30 to 180 mins | Mus musculus | 1 | ALA4138226 | cell-based format | Scientific Literature | |
17. | ALA4143368 | Binding | Activation of Keap1/Nrf2 in mouse LPS-induced RAW264.7 cells assessed as change in Fosl1 expression level at 4 to 12 uM pretreated for 1 hr followed by LPS addition measured after 30 to 180 mins | Mus musculus | 1 | ALA4138226 | cell-based format | Scientific Literature | |
18. | ALA4143369 | Binding | Activation of Keap1/Nrf2 in mouse LPS-induced RAW264.7 cells assessed as change in Cd300lb expression level at 4 to 12 uM pretreated for 1 hr followed by LPS addition measured after 30 to 180 mins | Mus musculus | 1 | ALA4138226 | cell-based format | Scientific Literature | |
19. | ALA4143370 | Binding | Activation of Keap1/Nrf2 in mouse LPS-induced RAW264.7 cells assessed as change in lfit1 expression level at 4 to 12 uM pretreated for 1 hr followed by LPS addition measured after 30 to 180 mins | Mus musculus | 1 | ALA4138226 | cell-based format | Scientific Literature | |
20. | ALA4143371 | Binding | Activation of Keap1/Nrf2 in mouse LPS-induced RAW264.7 cells assessed as change in Ccl22 expression level at 4 to 12 uM pretreated for 1 hr followed by LPS addition measured after 30 to 180 mins | Mus musculus | 1 | ALA4138226 | cell-based format | Scientific Literature |