| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4134035 | F | Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calcium mobilization preincubated for 2.3 mins followed by glutamate addition measured for 2.6 mins by Fluo-4 AM dye based fluorescence assay | Rattus norvegicus | 14 | ALA4130451 | cell-based format | Scientific Literature | |
| 2. | ALA4134036 | F | Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calcium mobilization by measuring minimum glutamate response preincubated for 2.3 mins followed by glutamate addition measured for 2.6 mins by Fluo-4 AM dye based fluorescence assay relative to glutamate | Rattus norvegicus | 13 | ALA4130451 | cell-based format | Scientific Literature | |
| 3. | ALA4134037 | F | Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as increase in glutamate induced-calcium mobilization preincubated for 2.3 mins followed by glutamate addition measured for 1.9 mins by Fluo-4 AM dye based fluorescence assay | Rattus norvegicus | 13 | ALA4130451 | cell-based format | Scientific Literature | |
| 4. | ALA4134039 | F | Negative allosteric modulation of rat mGlu2 receptor expressed in HEK293 cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calcium mobilization preincubated for 2.3 mins followed by glutamate addition measured for 1.9 mins by Fluo-4 AM dye based fluorescence assay | Rattus norvegicus | 3 | ALA4130451 | cell-based format | Scientific Literature | |
| 5. | ALA4134041 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 15 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA4130451 | microsome format | Scientific Literature | |
| 6. | ALA4134042 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 15 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA4130451 | microsome format | Scientific Literature | |
| 7. | ALA4134043 | A | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 15 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA4130451 | microsome format | Scientific Literature | |
| 8. | ALA4134044 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 15 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA4130451 | microsome format | Scientific Literature | |
| 9. | ALA4134045 | A | Fraction unbound in rat plasma at 5 uM after 4 hrs by equilibrium dialysis based LC/MS/MS analysis | Rattus norvegicus | 3 | ALA4130451 | cell-free format | Scientific Literature | |
| 10. | ALA4134046 | A | Fraction unbound in human plasma at 5 uM after 4 hrs by equilibrium dialysis based LC/MS/MS analysis | Homo sapiens | 2 | ALA4130451 | cell-free format | Scientific Literature | |
| 11. | ALA4134047 | A | Fraction unbound in rat brain homogenate at 5 uM after 6 hrs by equilibrium dialysis based LC/MS/MS analysis | Rattus norvegicus | 2 | ALA4130451 | tissue-based format | Scientific Literature | |
| 12. | ALA4134048 | A | Brain to plasma partition coefficient, Kp of the compound in rat | Rattus norvegicus | 2 | ALA4130451 | cell-free format | Scientific Literature | |
| 13. | ALA4134049 | A | Unbound brain-to-plasma concentration ratio in rat | Rattus norvegicus | 2 | ALA4130451 | cell-free format | Scientific Literature | |
| 14. | ALA4134050 | F | Negative allosteric modulation of human mGlu1 receptor expressed in TREX293 cells assessed as inhibition of glutamate induced-calcium mobilization preincubated for 2.3 mins followed by glutamate addition measured for 2.6 mins by Fluo-4 AM dye based fluorescence assay | Homo sapiens | 1 | ALA4130451 | cell-based format | Scientific Literature | |
| 15. | ALA4134051 | F | Negative allosteric modulation of human mGlu6 receptor expressed in HEK/GIRK cells assessed as inhibition of glutamate induced-calcium mobilization preincubated for 2.3 mins followed by glutamate addition measured for 2.6 mins by Fluo-4 AM dye based fluorescence assay | Homo sapiens | 1 | ALA4130451 | cell-based format | Scientific Literature | |
| 16. | ALA4134052 | F | Negative allosteric modulation of rat mGlu4 receptor expressed in HEK/GIRK cells assessed as inhibition of glutamate induced-calcium mobilization preincubated for 2.3 mins followed by glutamate addition measured for 2.6 mins by Fluo-4 AM dye based fluorescence assay | Rattus norvegicus | 1 | ALA4130451 | cell-based format | Scientific Literature | |
| 17. | ALA4134053 | F | Negative allosteric modulation of rat mGlu7 receptor expressed in HEK/GIRK cells assessed as inhibition of L-AP4 induced-calcium mobilization preincubated for 2.3 mins followed by L-AP4 addition measured for 2.6 mins by Fluo-4 AM dye based fluorescence assay | Rattus norvegicus | 1 | ALA4130451 | cell-based format | Scientific Literature | |
| 18. | ALA4134054 | F | Negative allosteric modulation of rat mGlu8 receptor expressed in HEK/GIRK cells assessed as inhibition of glutamate induced-calcium mobilization preincubated for 2.3 mins followed by glutamate addition measured for 2.6 mins by Fluo-4 AM dye based fluorescence assay | Rattus norvegicus | 1 | ALA4130451 | cell-based format | Scientific Literature | |
| 19. | ALA4134055 | A | Fraction unbound in mouse plasma at 5 uM after 4 hrs by equilibrium dialysis based LC/MS/MS analysis | Mus musculus | 1 | ALA4130451 | cell-free format | Scientific Literature | |
| 20. | ALA4134056 | P | Kinetic solubility of the compound in PBS at pH 7.4 | 1 | ALA4130451 | small-molecule physicochemical format | Scientific Literature |
The page will load shortly, Thanks for your patience!