| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4158211 | A | Half life in human liver microsomes at 1 uM in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 46 | microsome format | Scientific Literature | ||
| 2. | ALA4158212 | A | Half life in rat liver microsomes at 1 uM in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 46 | microsome format | Scientific Literature | ||
| 3. | ALA4158213 | A | Half life in mouse liver microsomes at 1 uM in presence of NADPH by LC-MS/MS analysis | Mus musculus | 46 | microsome format | Scientific Literature | ||
| 4. | ALA4158215 | B | Inhibition of recombinant human full length MMP13 expressed in mouse NS0 cells using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 45 | cell-based format | Scientific Literature | ||
| 5. | ALA4158218 | B | Inhibition of recombinant human MMP1 expressed in mouse NS0 cells using Knight substrate preincubated for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 45 | cell-based format | Scientific Literature | ||
| 6. | ALA4158219 | B | Inhibition of recombinant human MMP2 using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 45 | single protein format | Scientific Literature | ||
| 7. | ALA4158220 | B | Inhibition of recombinant human MMP8 expressed in mouse NS0 cells using Knight substrate preincubated for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 45 | cell-based format | Scientific Literature | ||
| 8. | ALA4158221 | B | Inhibition of recombinant human MMP9 using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 45 | single protein format | Scientific Literature | ||
| 9. | ALA4158222 | B | Inhibition of recombinant human MMP14 expressed in Escherichia coli using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 45 | assay format | Scientific Literature | ||
| 10. | ALA4158223 | B | Selectivity ratio of IC50 for recombinant human MMP1 expressed in mouse NS0 cells to IC50 for recombinant human full length MMP13 expressed in mouse NS0 cells | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 11. | ALA4158224 | B | Selectivity ratio of IC50 for recombinant human MMP2 to IC50 for recombinant human full length MMP13 expressed in mouse NS0 cells | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 12. | ALA4158225 | B | Selectivity ratio of IC50 for recombinant human MMP8 expressed in mouse NS0 cells to IC50 for recombinant human full length MMP13 expressed in mouse NS0 cells | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 13. | ALA4158226 | B | Selectivity ratio of IC50 for recombinant human MMP9 to IC50 for recombinant human full length MMP13 expressed in mouse NS0 cells | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 14. | ALA4158227 | B | Selectivity ratio of IC50 for recombinant human MMP14 expressed in Escherichia coli to IC50 for recombinant human full length MMP13 expressed in mouse NS0 cells | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 15. | ALA4158230 | B | Inhibition of recombinant human full length MMP13 expressed in mouse NS0 cells assessed as reduction in enzyme-mediated type-2 collagen cleavage at 20 uM after 22 hrs by SDS-PAGE analysis relative to control | Homo sapiens | 32 | cell-based format | Scientific Literature | ||
| 16. | ALA4158232 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 17. | ALA4158233 | A | Cmax in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 18. | ALA4158234 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 19. | ALA4158235 | A | Inhibition of CYP1A2 in human liver microsomes at 10 uM using phenaceten as substrate after 10 mins in presence of NADPH relative to control | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 20. | ALA4158236 | A | Inhibition of CYP2C9 in human liver microsomes at 10 uM using tolbutamide as substrate after 10 mins in presence of NADPH relative to control | Homo sapiens | 5 | microsome format | Scientific Literature |
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