| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4144584 | A | Cytotoxicity against rat RBL2H3 cells assessed as cell viability at 400 uM after 24 hrs by MTT assay relative to control | Rattus norvegicus | 3 | ALA4138279 | cell-based format | Scientific Literature | |
| 2. | ALA4144585 | F | Antiallergic activity in rat RBL2H3 cells assessed as inhibition of A23187-induced beta hexosaminidase release at 1 uM pretreated for 20 hrs followed by A23187 addition measured after 1 hr by p-NAG substrate based assay relative to control | Rattus norvegicus | 3 | ALA4138279 | cell-based format | Scientific Literature | |
| 3. | ALA4144586 | F | Antiallergic activity in rat RBL2H3 cells assessed as inhibition of A23187-induced beta hexosaminidase release at 10 uM pretreated for 20 hrs followed by A23187 addition measured after 1 hr by p-NAG substrate based assay relative to control | Rattus norvegicus | 3 | ALA4138279 | cell-based format | Scientific Literature | |
| 4. | ALA4144587 | F | Antiallergic activity in rat RBL2H3 cells assessed as inhibition of A23187-induced beta hexosaminidase release at 100 uM pretreated for 20 hrs followed by A23187 addition measured after 1 hr by p-NAG substrate based assay relative to control | Rattus norvegicus | 3 | ALA4138279 | cell-based format | Scientific Literature | |
| 5. | ALA4144588 | F | Antiallergic activity in rat RBL2H3 cells assessed as inhibition of A23187-induced beta hexosaminidase release at 200 uM pretreated for 20 hrs followed by A23187 addition measured after 1 hr by p-NAG substrate based assay relative to control | Rattus norvegicus | 3 | ALA4138279 | cell-based format | Scientific Literature | |
| 6. | ALA4144589 | F | Antiallergic activity in rat RBL2H3 cells assessed as inhibition of A23187-induced beta hexosaminidase release at 400 uM pretreated for 20 hrs followed by A23187 addition measured after 1 hr by p-NAG substrate based assay relative to control | Rattus norvegicus | 3 | ALA4138279 | cell-based format | Scientific Literature | |
| 7. | ALA4144590 | F | Antiallergic activity in anti-DNP IgE-sensitized rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta hexosaminidase release at 1 uM pretreated for 20 hrs followed by anti-DNP IgE-sensitization for 2 hrs and subsequent DNP-BSA addition measured after 1 hr by p-NAG substrate based assay relative to control | Rattus norvegicus | 3 | ALA4138279 | cell-based format | Scientific Literature | |
| 8. | ALA4144591 | F | Antiallergic activity in anti-DNP IgE-sensitized rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta hexosaminidase release at 10 uM pretreated for 20 hrs followed by anti-DNP IgE-sensitization for 2 hrs and subsequent DNP-BSA addition measured after 1 hr by p-NAG substrate based assay relative to control | Rattus norvegicus | 3 | ALA4138279 | cell-based format | Scientific Literature | |
| 9. | ALA4144592 | F | Antiallergic activity in anti-DNP IgE-sensitized rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta hexosaminidase release at 100 uM pretreated for 20 hrs followed by anti-DNP IgE-sensitization for 2 hrs and subsequent DNP-BSA addition measured after 1 hr by p-NAG substrate based assay relative to control | Rattus norvegicus | 3 | ALA4138279 | cell-based format | Scientific Literature | |
| 10. | ALA4144593 | F | Antiallergic activity in anti-DNP IgE-sensitized rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta hexosaminidase release at 200 uM pretreated for 20 hrs followed by anti-DNP IgE-sensitization for 2 hrs and subsequent DNP-BSA addition measured after 1 hr by p-NAG substrate based assay relative to control | Rattus norvegicus | 3 | ALA4138279 | cell-based format | Scientific Literature | |
| 11. | ALA4144594 | F | Antiallergic activity in anti-DNP IgE-sensitized rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta hexosaminidase release at 400 uM pretreated for 20 hrs followed by anti-DNP IgE-sensitization for 2 hrs and subsequent DNP-BSA addition measured after 1 hr by p-NAG substrate based assay relative to control | Rattus norvegicus | 3 | ALA4138279 | cell-based format | Scientific Literature | |
| 12. | ALA4144597 | F | Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase inhibitable reduction of ferricytochrome c based spectrophotometric assay | Homo sapiens | 4 | ALA4138279 | cell-based format | Scientific Literature | |
| 13. | ALA4144598 | F | Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation at 10 uM pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase inhibitable reduction of ferricytochrome c based spectrophotometric assay relative to control | Homo sapiens | 4 | ALA4138279 | cell-based format | Scientific Literature | |
| 14. | ALA4144599 | F | Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate | Homo sapiens | 4 | ALA4138279 | cell-based format | Scientific Literature | |
| 15. | ALA4144600 | F | Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release at 10 uM pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate relative to control | Homo sapiens | 4 | ALA4138279 | cell-based format | Scientific Literature | |
| 16. | ALA4144601 | F | Antiallergic activity in anti-DNP IgE-sensitized rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta hexosaminidase release pretreated for 10 mins followed by DNP-BSA addition measured after 10 mins by p-NAG substrate based assay | Rattus norvegicus | 4 | ALA4138279 | cell-based format | Scientific Literature | |
| 17. | ALA4724456 | A | Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability by MTT assay | Mus musculus | 17 | ALA4715890 | cell-based format | Scientific Literature | |
| 18. | ALA4724457 | F | Induction of glucose uptake in mouse C2C12 cells at 1 ug/ml | Mus musculus | 11 | ALA4715890 | cell-based format | Scientific Literature | |
| 19. | ALA4724458 | F | Induction of glucose uptake in mouse C2C12 cells at 1 ug/ml in presence of insulin | Mus musculus | 11 | ALA4715890 | cell-based format | Scientific Literature | |
| 20. | ALA4724459 | B | Inhibition of PTP1B in mouse PA-induced insulin-resistance C2C12 cells assessed as increase in glucose consumption at 1 ug/ml in presence of insulin after 16 hrs | Mus musculus | 8 | ALA4715890 | tissue-based format | Scientific Literature |
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