| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4133148 | B | Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of ATP-induced propidium iodide uptake after 25 mins by flow cytometric analysis | Mus musculus | 8 | single protein format | Scientific Literature | ||
| 2. | ALA4133149 | B | Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of ATP-induced current at holding potential of -60 mV preincubated for 5 mins followed by ATP addition measured after 5 mins by Whole cell patch-clamp analysis | Mus musculus | 8 | single protein format | Scientific Literature | ||
| 3. | ALA4133151 | B | Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced ethidium iodide uptake preincubated for 10 mins followed by ATP addition measured after 20 mins by spectrofluorometric analysis | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 4. | ALA4133152 | B | Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of BzATP-induced ethidium iodide uptake after 30 mins by spectrofluorometric analysis | Mus musculus | 3 | single protein format | Scientific Literature | ||
| 5. | ALA4133153 | B | Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of BzATP-induced current at holding potential of -60 mV preincubated for 5 mins followed by BzATP addition measured after 5 mins by Whole cell patch-clamp analysis | Mus musculus | 3 | single protein format | Scientific Literature | ||
| 6. | ALA4133194 | B | Antagonist activity at human P2X7 receptor expressed in Swiss mouse peritoneal macrophages assessed as inhibition of ATP-induced propidium iodide uptake at 750 nM after 30 mins by FLIPR assay relative to 1 mM ATP | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 7. | ALA4133195 | T | Toxicity in Swiss mouse peritoneal macrophages assessed as LDH release at 750 nM after 60 mins relative to 0.05% Triton X-100 | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4133196 | B | Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced ethidium iodide uptake at 750 nM preincubated for 10 mins followed by ATP addition measured after 20 mins by FLIPR assay relative to 1 mM ATP | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4252246 | B | Antagonist activity at P2X7R in Swiss Webster mouse peritoneal macrophages assessed as inhibition of ATP-induced propidium iodide uptake preincubated for 10 mins followed by ATP induction measured after 25 mins by fluorescence assay | Mus musculus | 11 | single protein format | Scientific Literature | ||
| 10. | ALA4252247 | A | Cytotoxicity against Swiss Webster mouse peritoneal macrophages by LDH release assay | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 11. | ALA4252248 | T | Selectivity index, ratio of CC50 for Swiss Webster mouse peritoneal macrophages to IC50 for antagonist activity at P2X7R in Swiss Webster mouse peritoneal macrophages | Mus musculus | 5 | assay format | Scientific Literature | ||
| 12. | ALA4252249 | F | Antiinflammatory activity in LPS/IFNgamma-differentiated human THP1 cells assessed as inhibition of ATP-induced IL-1beta release after 30 mins by ELISA | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 13. | ALA4252250 | F | Antiinflammatory activity in LPS/IFNgamma-differentiated Swiss Webster mouse peritoneal macrophages assessed as inhibition of ATP-induced IL-1beta release preincubated for 15 mins followed by ATP/LPS challenge measured after 30 mins by sandwich ELISA | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 14. | ALA4252251 | B | Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced ethidium iodide uptake preincubated for 10 mins followed by ATP induction measured after 25 mins by fluorescence assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 15. | ALA4252519 | B | Inhibition of wild type alpha-synuclein (unknown origin) aggregation expressed in Escherichia coli BL21 after 30 days by thioflavin T staining-based spectrofluorimetric analysis relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 16. | ALA4252520 | B | Inhibition of wild type alpha-synuclein (unknown origin) aggregation expressed in Escherichia coli BL21 after 30 days by congo dye-based UV-VIS spectrophotometric analysis | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 17. | ALA4252521 | B | Inhibition of wild type alpha-synuclein (unknown origin) aggregation expressed in Escherichia coli BL21 after 30 days by thioflavin T staining-based spectrofluorimetric analysis | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 18. | ALA4252522 | B | Inhibition of wild type alpha-synuclein (unknown origin) aggregation expressed in Escherichia coli BL21 assessed as amorphous aggregates formation after 30 days by TEM analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA4252523 | B | Inhibition of wild type alpha-synuclein (unknown origin) aggregation expressed in Escherichia coli BL21 assessed as globular aggregates formation after 30 days by TEM analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA4252525 | B | Inhibition of wild type alpha-synuclein (unknown origin) aggregation expressed in Escherichia coli BL21 assessed as oligomer height after 30 days by AFM analysis (Rvb = 1.9 +/- 1.5 nm) | Homo sapiens | 2 | assay format | Scientific Literature |
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