# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4158045 | B | Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 31 | ALA4152363 | cell-based format | Scientific Literature | |
2. | ALA4158046 | B | Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs by luciferase reporter gene assay | Homo sapiens | 31 | ALA4152363 | cell-based format | Scientific Literature | |
3. | ALA4158047 | B | Inhibition of NF-kappaB stimulated STAT3 activation in human AD293 cells incubated with NF-kappaB for 16 hrs followed by compound addition measured after 4 hrs by luciferase reporter gene assay | Homo sapiens | 31 | ALA4152363 | cell-based format | Scientific Literature | |
4. | ALA4158048 | A | Cytotoxicity against human AD293 cells | Homo sapiens | 31 | ALA4152363 | cell-based format | Scientific Literature | |
5. | ALA4158049 | B | Inhibition of IFNgamma-stimulated STAT3 activation in human HeLa cells incubated with IFNgamma for 16 hrs followed by compound addition measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 31 | ALA4152363 | cell-based format | Scientific Literature | |
6. | ALA4158050 | B | Inhibition of NF-kappaB stimulated STAT3 activation in human HeLa cells incubated with NF-kappaB for 16 hrs followed by compound addition measured after 4 hrs by luciferase reporter gene assay | Homo sapiens | 31 | ALA4152363 | cell-based format | Scientific Literature | |
7. | ALA4158051 | A | Cytotoxicity against human HeLa cells | Homo sapiens | 31 | ALA4152363 | cell-based format | Scientific Literature | |
8. | ALA4158052 | B | Inhibition of IFNgamma-stimulated STAT1 phosphorylation at Tyr701 residues in human AD293 cell lysates incubated with IFNgamma followed by compound addition at 10 uM by Western blot analysis | Homo sapiens | 5 | ALA4152363 | single protein format | Scientific Literature | |
9. | ALA4158053 | B | Inhibition of IFNgamma-stimulated STAT3 phosphorylation at Tyr705 residues in human AD293 cell lysates incubated with IFNgamma followed by compound addition at 10 uM by Western blot analysis | Homo sapiens | 6 | ALA4152363 | single protein format | Scientific Literature | |
10. | ALA4158054 | B | Inhibition of IFNgamma-stimulated GFP/FLAG-tagged STAT3 dimerization in human AD293 cells at 10 uM incubated for 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA4152363 | cell-based format | Scientific Literature | |
11. | ALA4158056 | B | Inhibition of DNA binding activity of STAT3 in human AD293 cells up to 40 uM | Homo sapiens | 1 | ALA4152363 | cell-based format | Scientific Literature | |
12. | ALA4158057 | T | Toxicity in Balb/c mouse assessed as change in body weight at 30 mg/kg, po qd for 7 days | Mus musculus | 1 | ALA4152363 | organism-based format | Scientific Literature | |
13. | ALA4158058 | F | Hepatoprotective activity against CCL4-induced acute liver damage in Balb/c mouse assessed as decrease in hepatic damage at 30 mg/kg, po qd for 7 days measured after 16 hrs post CCL4 challenge by hematoxylin-eosin staining based light microscopy | Mus musculus | 1 | ALA4152363 | organism-based format | Scientific Literature | |
14. | ALA4158059 | F | Hepatoprotective activity against CCL4-induced acute liver damage in Balb/c mouse assessed as decrease in number of necrotic cells at 30 mg/kg, po qd for 7 days measured after 16 hrs post CCL4 challenge by hematoxylin-eosin staining based light microscopy | Mus musculus | 1 | ALA4152363 | organism-based format | Scientific Literature | |
15. | ALA4158060 | F | Hepatoprotective activity against CCL4-induced acute liver damage in Balb/c mouse assessed as increase in number of PCNA positive cells at 30 mg/kg, po qd for 7 days measured after 16 hrs post CCL4 challenge by hematoxylin staining based immunohistochemistry method | Mus musculus | 1 | ALA4152363 | organism-based format | Scientific Literature | |
16. | ALA4158061 | F | Hepatoprotective activity against CCL4-induced acute liver damage in Balb/c mouse assessed as increase in number of Ki67 positive cells at 30 mg/kg, po qd for 7 days measured after 16 hrs post CCL4 challenge by hematoxylin staining based immunohistochemistry method | Mus musculus | 1 | ALA4152363 | organism-based format | Scientific Literature | |
17. | ALA4158062 | F | Antifibrotic activity in CCL4-induced acute liver damage Balb/c mouse model assessed as decrease in collagen deposition in liver at 30 mg/kg, po qd for 7 days measured after 16 hrs post CCL4 challenge by masson trichome staining based assay | Mus musculus | 1 | ALA4152363 | organism-based format | Scientific Literature | |
18. | ALA4158063 | F | Antifibrotic activity in CCL4-induced acute liver damage Balb/c mouse model assessed as decrease in alpha-SMA expression in areas surrounding blood vessels at 30 mg/kg, po qd for 7 days measured after 16 hrs post CCL4 challenge by masson trichome staining based assay | Mus musculus | 1 | ALA4152363 | organism-based format | Scientific Literature | |
19. | ALA4158064 | F | Reduction in MMP10 mRNA expression level in CCL4-induced acute liver damage in Balb/c mouse at 30 mg/kg, po qd for 7 days measured after 16 hrs post CCL4 challenge by qRT-PCR method | Mus musculus | 1 | ALA4152363 | organism-based format | Scientific Literature | |
20. | ALA4158065 | F | Reduction in MMP13 mRNA expression level in CCL4-induced acute liver damage in Balb/c mouse at 30 mg/kg, po qd for 7 days measured after 16 hrs post CCL4 challenge by qRT-PCR method | Mus musculus | 1 | ALA4152363 | organism-based format | Scientific Literature |