# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4153629 | Binding | Inhibition of yeast GCN5 (99 to 262 residues) expressed in Escherichia coli BL21 (DE3) at 33 uM preincubated for 15 mins followed by biotin tagged H3 peptide ( 1 to 23 residues) and [3H]-Ac-CoA addition and measured after 60 mins by radioactive acetylation assay | Saccharomyces cerevisiae | 5 | ALA4152219 | assay format | Scientific Literature | |
2. | ALA4153630 | Functional | Antiproliferative activity against human MV4-11 cells after 3 days by celltiter-glo luminescent assay | Homo sapiens | 2 | ALA4152219 | cell-based format | Scientific Literature | |
3. | ALA4153649 | Binding | Inhibition of GCN5 in human MV4-11 cells assessed as reduction of acetylated H3K14 level up to 100 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4152219 | cell-based format | Scientific Literature | |
4. | ALA4628753 | ADME | Cytotoxicity against human SH-SY5Y cells at 100 uM by MTT assay relative to control | Homo sapiens | 3 | ALA4627331 | cell-based format | Scientific Literature | |
5. | ALA4628754 | Binding | Selectivity index, ratio of IC50 for equine BuchE using butyrylthiocholine as substrate by Ellman's method to IC50 for human BuchE | 2 | ALA4627331 | assay format | Scientific Literature | ||
6. | ALA4628755 | Binding | Selectivity index, ratio of IC50 for human AchE to IC50 for human BuchE | Homo sapiens | 3 | ALA4627331 | assay format | Scientific Literature | |
7. | ALA4628756 | ADME | Inhibition of human AchE | Homo sapiens | 3 | ALA4627331 | single protein format | Scientific Literature | |
8. | ALA4628757 | ADME | Inhibition of human AchE at 100 uM relative to control | Homo sapiens | 1 | ALA4627331 | single protein format | Scientific Literature | |
9. | ALA4628758 | Binding | Inhibition of human BuchE | Homo sapiens | 3 | ALA4627331 | single protein format | Scientific Literature | |
10. | ALA4628759 | Binding | Selectivity index, ratio of IC50 for electric eel AchE using acetylthiocholine as substrate by Ellman's method to IC50 for equine BuchE using butyrylthiocholine as substrate by Ellman's method | 9 | ALA4627331 | assay format | Scientific Literature | ||
11. | ALA4628760 | ADME | Inhibition of electric eel AchE using acetylthiocholine as substrate by Ellman's method | Electrophorus electricus | 9 | ALA4627331 | single protein format | Scientific Literature | |
12. | ALA4628761 | ADME | Inhibition of electric eel AchE at 100 uM using acetylthiocholine as substrate by Ellman's method relative to control | Electrophorus electricus | 8 | ALA4627331 | single protein format | Scientific Literature | |
13. | ALA4628762 | Binding | Inhibition of equine BuchE using butyrylthiocholine as substrate by Ellman's method | Equus caballus | 9 | ALA4627331 | single protein format | Scientific Literature |