| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4356553 | Physicochemical | Aqueous solubility of compound at 2 mg measured for 24 hrs by HPLC analysis | 10 | ALA4354822 | small-molecule physicochemical format | Scientific Literature | ||
| 2. | ALA4356554 | ADME | Metabolic stability in human liver microsomes at 1 uM measured up to 45 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA4354822 | microsome format | Scientific Literature | |
| 3. | ALA4356555 | ADME | Metabolic stability in rat liver microsomes at 1 uM measured up to 45 mins in presence of NADPH by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA4354822 | microsome format | Scientific Literature | |
| 4. | ALA4356556 | ADME | Intrinsic clearance in human liver microsomes assessed per mg protein at 1 uM measured up to 45 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA4354822 | microsome format | Scientific Literature | |
| 5. | ALA4356557 | ADME | Intrinsic clearance in rat liver microsomes assessed per mg protein at 1 uM measured up to 45 mins in presence of NADPH by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA4354822 | microsome format | Scientific Literature | |
| 6. | ALA4147209 | Functional | Antiviral activity against wild type HIV1 3B infected in human MT4 cells assessed as reduction of virus-induced cytopathic effect after 4 days by MTT assay | Human immunodeficiency virus 1 | 26 | ALA4145492 | organism-based format | Scientific Literature | |
| 7. | ALA4147210 | Functional | Antiviral activity against HIV2 ROD infected in human MT4 cells assessed as reduction of virus-induced cytopathic effect after 4 days by MTT assay | Human immunodeficiency virus 2 | 22 | ALA4145492 | organism-based format | Scientific Literature | |
| 8. | ALA4147211 | ADME | Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 4 days by MTT assay | Homo sapiens | 26 | ALA4145492 | cell-based format | Scientific Literature | |
| 9. | ALA4147212 | Toxicity | Selectivity index, ratio of CC50 for human MT4 cells to EC50 for wild type HIV1 3B | 26 | ALA4145492 | assay format | Scientific Literature | ||
| 10. | ALA4147213 | Functional | Antiviral activity against HIV1 harboring reverse transcriptase L100I mutant infected in human MT4 cells assessed as reduction of virus-induced cytopathic effect after 4 days by MTT assay | Human immunodeficiency virus 1 | 8 | ALA4145492 | organism-based format | Scientific Literature | |
| 11. | ALA4147214 | Functional | Antiviral activity against HIV1 harboring reverse transcriptase K103N mutant infected in human MT4 cells assessed as reduction of virus-induced cytopathic effect after 4 days by MTT assay | Human immunodeficiency virus 1 | 8 | ALA4145492 | organism-based format | Scientific Literature | |
| 12. | ALA4147215 | Functional | Antiviral activity against HIV1 harboring reverse transcriptase Y181C mutant infected in human MT4 cells assessed as reduction of virus-induced cytopathic effect after 4 days by MTT assay | Human immunodeficiency virus 1 | 8 | ALA4145492 | organism-based format | Scientific Literature | |
| 13. | ALA4147216 | Functional | Antiviral activity against HIV1 harboring reverse transcriptase Y188L mutant infected in human MT4 cells assessed as reduction of virus-induced cytopathic effect after 4 days by MTT assay | Human immunodeficiency virus 1 | 8 | ALA4145492 | organism-based format | Scientific Literature | |
| 14. | ALA4147217 | Functional | Antiviral activity against HIV1 harboring reverse transcriptase E138K mutant infected in human MT4 cells assessed as reduction of virus-induced cytopathic effect after 4 days by MTT assay | Human immunodeficiency virus 1 | 8 | ALA4145492 | organism-based format | Scientific Literature | |
| 15. | ALA4147218 | Functional | Antiviral activity against HIV1 RES056 harboring reverse transcriptase K103 N/Y181C double mutant infected in human MT4 cells assessed as reduction of virus-induced cytopathic effect after 4 days by MTT assay | Human immunodeficiency virus 1 | 8 | ALA4145492 | organism-based format | Scientific Literature | |
| 16. | ALA4147219 | Functional | Antiviral activity against HIV1 harboring reverse transcriptase F227L/V106A double mutant infected in human MT4 cells assessed as reduction of virus-induced cytopathic effect after 4 days by MTT assay | Human immunodeficiency virus 1 | 8 | ALA4145492 | organism-based format | Scientific Literature | |
| 17. | ALA4147220 | Binding | Inhibition of recombinant wild type HIV1 reverse transcriptase p66/p51 using poly (rA)/anoligo (dT)16 as template/primer assessed as inhibition of biotin-dUTP incorporation after 40 mins by Pico-Green staining based fluorescence assay | Human immunodeficiency virus 1 | 24 | ALA4145492 | single protein format | Scientific Literature | |
| 18. | ALA4809221 | ADME | Metabolic stability in human liver microsomes assessed as intrinsic clearance per mg protein | Homo sapiens | 3 | ALA4808181 | microsome format | Scientific Literature | |
| 19. | ALA4809223 | ADME | Metabolic stability in rat liver microsomes assessed as intrinsic clearance per mg protein | Rattus norvegicus | 3 | ALA4808181 | microsome format | Scientific Literature | |
| 20. | ALA4809224 | ADME | Metabolic stability in human liver microsomes assessed as half life | Homo sapiens | 3 | ALA4808181 | microsome format | Scientific Literature |
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