# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4131389 | F | Antidiabetic activity in Zucker rat chronic ob/ob model assessed as fasting blood glucose level at 3 mg/kg, po qd measured on day 14 (Rvb = 337.5 +/- 17.9 mg/dl) | Rattus norvegicus | 1 | ALA4130359 | organism-based format | Scientific Literature | |
2. | ALA4131392 | B | Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18 hrs by TR-FRET assay | Homo sapiens | 31 | ALA4130359 | single protein format | Scientific Literature | |
3. | ALA4131393 | F | Decrease in fed plasma insulin level in Zucker rat sub-chronic fa/fa prediabetic model assessed as change in plasma insulin level at 10 mg/kg, po qd for 4 days measured on day 5 relative to control | Rattus norvegicus | 31 | ALA4130359 | organism-based format | Scientific Literature | |
4. | ALA4131394 | F | Decrease in fed plasma triglyceride level in Zucker rat sub-chronic fa/fa prediabetic model assessed as change in plasma triglyceride level at 10 mg/kg, po qd for 4 days measured on day 5 relative to control | Rattus norvegicus | 31 | ALA4130359 | organism-based format | Scientific Literature | |
5. | ALA4131398 | F | Decrease in fed plasma glucose level in Zucker rat sub-chronic fa/fa prediabetic model at 10 mg/kg, po qd for 4 days measured on day 5 relative to control | Rattus norvegicus | 3 | ALA4130359 | organism-based format | Scientific Literature | |
6. | ALA4131401 | F | Antidiabetic activity in Zucker rat sub-chronic fa/fa prediabetic model assessed as decrease in plasma glucose AUC (0 to 120 mins) at 10 mg/kg, po qd during 10 days study by OGTT relative to control | Rattus norvegicus | 2 | ALA4130359 | organism-based format | Scientific Literature | |
7. | ALA4131402 | T | Toxicity in Zucker rat sub-chronic fa/fa prediabetic model assessed as increase in body weight at 10 mg/kg, po qd during 10 days study | Rattus norvegicus | 2 | ALA4130359 | organism-based format | Scientific Literature | |
8. | ALA4131403 | T | Toxicity in Zucker rat sub-chronic fa/fa prediabetic model assessed as increase in food consumption at 10 mg/kg, po qd during 10 days study | Rattus norvegicus | 2 | ALA4130359 | organism-based format | Scientific Literature | |
9. | ALA4131404 | T | Toxicity in Zucker rat sub-chronic fa/fa prediabetic model assessed as effect on liver enzymes at 10 mg/kg, po qd during 10 days study | Rattus norvegicus | 2 | ALA4130359 | organism-based format | Scientific Literature | |
10. | ALA4131405 | B | Inhibition of fluormone ES2 green binding to recombinant full length human ERalpha expressed in insect cells by fluorescence polarization assay | Homo sapiens | 2 | ALA4130359 | cell-based format | Scientific Literature | |
11. | ALA4131406 | B | Inhibition of fluormone ES2 binding to recombinant full length human ERbeta expressed in insect cells by fluorescence polarization assay | Homo sapiens | 2 | ALA4130359 | cell-based format | Scientific Literature | |
12. | ALA4131407 | B | Inhibition of fluormone PPARgamma Green binding to recombinant N-terminal GST-tagged human PPARgamma LBD by fluorescence polarization assay | Homo sapiens | 2 | ALA4130359 | single protein format | Scientific Literature | |
13. | ALA4131408 | B | Agonist activity at recombinant GST-tagged human PPARalpha LBD assessed as fluorescein-labeled coactivator peptide recruitment preincubated with enzyme followed by coactivator addition by LanthaScreen TR-FRET assay | Homo sapiens | 1 | ALA4130359 | single protein format | Scientific Literature | |
14. | ALA4131409 | B | Agonist activity at recombinant GST-tagged human PPARdelta LBD assessed as fluorescein-labeled coactivator peptide recruitment preincubated with enzyme followed by coactivator addition by LanthaScreen TR-FRET assay | Homo sapiens | 1 | ALA4130359 | single protein format | Scientific Literature | |
15. | ALA4131410 | B | Agonist activity at recombinant GST-tagged human LXRalpha LBD assessed as fluorescein-labeled coactivator peptide recruitment preincubated with enzyme followed by coactivator addition by LanthaScreen TR-FRET assay | Homo sapiens | 1 | ALA4130359 | single protein format | Scientific Literature | |
16. | ALA4131411 | B | Agonist activity at recombinant GST-tagged human LXRbeta LBD assessed as fluorescein-labeled coactivator peptide recruitment preincubated with enzyme followed by coactivator addition by LanthaScreen TR-FRET assay | Homo sapiens | 1 | ALA4130359 | single protein format | Scientific Literature | |
17. | ALA4131412 | B | Agonist activity at recombinant GST-tagged human RXRalpha LBD assessed as fluorescein-labeled coactivator peptide recruitment preincubated with enzyme followed by coactivator addition by LanthaScreen TR-FRET assay | Homo sapiens | 1 | ALA4130359 | single protein format | Scientific Literature | |
18. | ALA4131413 | B | Agonist activity at recombinant GST-tagged human RARbeta LBD assessed as fluorescein-labeled coactivator peptide recruitment preincubated with enzyme followed by coactivator addition by LanthaScreen TR-FRET assay | Homo sapiens | 1 | ALA4130359 | single protein format | Scientific Literature | |
19. | ALA4131414 | B | Antagonist activity at recombinant GST-tagged human PPARalpha LBD assessed as inhibition of GW7647-induced fluorescein-labeled coactivator peptide recruitment preincubated with enzyme followed by coactivator addition by LanthaScreen TR-FRET assay | Homo sapiens | 1 | ALA4130359 | single protein format | Scientific Literature | |
20. | ALA4131415 | B | Antagonist activity at recombinant GST-tagged human PPARdelta LBD assessed as inhibition of GW0742-induced fluorescein-labeled coactivator peptide recruitment preincubated with enzyme followed by coactivator addition by LanthaScreen TR-FRET assay | Homo sapiens | 1 | ALA4130359 | single protein format | Scientific Literature |