# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4156823 | Binding | Inhibition of GST-tagged full length recombinant human VPS34 expressed in Baculovirus expression system using PI:PS as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr in presence of 50 uM ATP by ADP-Glo luminescence assay | Homo sapiens | 5 | ALA4152344 | assay format | Scientific Literature | |
2. | ALA4156824 | Binding | Inhibition of PI3Kalpha (unknown origin) using PIP2:PS as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr in presence of 10 uM ATP by ADP-Glo luminescence assay | Homo sapiens | 39 | ALA4152344 | single protein format | Scientific Literature | |
3. | ALA4156825 | Binding | Inhibition of PI3Kbeta (unknown origin) using PIP2:PS as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr in presence of 50 uM ATP by ADP-Glo luminescence assay | Homo sapiens | 39 | ALA4152344 | single protein format | Scientific Literature | |
4. | ALA4156826 | Binding | Inhibition of PI3Kgamma (unknown origin) using PIP2:PS as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr in presence of 50 uM ATP by ADP-Glo luminescence assay | Homo sapiens | 39 | ALA4152344 | single protein format | Scientific Literature | |
5. | ALA4156827 | Binding | Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr in presence of 50 uM ATP by ADP-Glo luminescence assay | Homo sapiens | 39 | ALA4152344 | single protein format | Scientific Literature | |
6. | ALA4156828 | Binding | Inhibition of N-terminal GST-tagged recombinant human PIK3C2A catalytic domain expressed in Baculovirus expression system using PI as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr in presence of 50 uM ATP by ADP-Glo luminescence assay | Homo sapiens | 5 | ALA4152344 | assay format | Scientific Literature | |
7. | ALA4156829 | Binding | Inhibition of N-terminal GST-tagged recombinant human PIK3C2B catalytic domain expressed in Baculovirus expression system using PI as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr in presence of 50 uM ATP by ADP-Glo luminescence assay | Homo sapiens | 5 | ALA4152344 | assay format | Scientific Literature | |
8. | ALA4156830 | Binding | Inhibition of PI4K3A (unknown origin) using PI:PS as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr in presence of 50 uM ATP by ADP-Glo luminescence assay | Homo sapiens | 5 | ALA4152344 | single protein format | Scientific Literature | |
9. | ALA4156831 | Binding | Inhibition of PI4K3B (unknown origin) using PI:PS as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr in presence of 50 uM ATP by ADP-Glo luminescence assay | Homo sapiens | 5 | ALA4152344 | single protein format | Scientific Literature | |
10. | ALA4156832 | Binding | Selectivity ratio of IC50 for PI3Kdelta (unknown origin) to IC50 for PI3Kgamma (unknown origin) | Homo sapiens | 3 | ALA4152344 | assay format | Scientific Literature | |
11. | ALA4156833 | Binding | Selectivity ratio of IC50 for PI3Kdelta (unknown origin) to IC50 for PI3Kalpha (unknown origin) | Homo sapiens | 1 | ALA4152344 | assay format | Scientific Literature | |
12. | ALA4156834 | Binding | Selectivity ratio of IC50 for PI3Kdelta (unknown origin) to IC50 for PI3Kbeta (unknown origin) | Homo sapiens | 1 | ALA4152344 | assay format | Scientific Literature | |
13. | ALA4156835 | Binding | Selectivity ratio of IC50 for PI3Kdelta (unknown origin) to IC50 for GST-tagged full length recombinant human VPS34 | Homo sapiens | 1 | ALA4152344 | assay format | Scientific Literature | |
14. | ALA4156836 | Binding | Selectivity ratio of IC50 for PI3Kdelta (unknown origin) to IC50 for PI4K3A (unknown origin) | Homo sapiens | 1 | ALA4152344 | assay format | Scientific Literature | |
15. | ALA4156837 | Binding | Selectivity ratio of IC50 for PI3Kdelta (unknown origin) to IC50 for PI4K3B (unknown origin) | Homo sapiens | 1 | ALA4152344 | assay format | Scientific Literature | |
16. | ALA4156838 | Binding | Inhibition of PI3Kalpha in mouse NIH-3T3 cells assessed as reduction in PDGF-BB-induced phosphorylation of AKT at Thr308 residues preincubated for 1 hr followed by PDGF-BB stimulation and measured after 10 mins by PAGE analysis | Mus musculus | 1 | ALA4152344 | cell-based format | Scientific Literature | |
17. | ALA4156839 | Binding | Inhibition of PI3Kbeta in mouse NIH-3T3 cells assessed as reduction in LPA-induced phosphorylation of AKT at Ser473 residues preincubated for 1 hr followed by LPA stimulation and measured after 10 mins by PAGE analysis | Mus musculus | 1 | ALA4152344 | cell-based format | Scientific Literature | |
18. | ALA4156840 | Binding | Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as C5a-induced reduction in phosphorylation of AKT at Ser473 residues preincubated for 1 hr followed by C5a stimulation and measured after 5 mins by PAGE analysis | Mus musculus | 1 | ALA4152344 | cell-based format | Scientific Literature | |
19. | ALA4156841 | Binding | Inhibition of PI3Kdelta in human Raji cells assessed as reduction in anti-IgM-antibody-induced phosphorylation of AKT at Thr308 residues preincubated for 1 hr followed by anti-IgM antibody stimulation and measured after 5 mins by PAGE analysis | Homo sapiens | 1 | ALA4152344 | cell-based format | Scientific Literature | |
20. | ALA4156842 | Functional | Growth inhibition of human PF382 cells after 72 hrs by CellTiter-Glo luminescent assay | Homo sapiens | 3 | ALA4152344 | cell-based format | Scientific Literature |