# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4155479 | B | Inhibition of Ca2+/calmodulin-induced recombinant human full length N-terminal GST-tagged PDE10A1 expressed in baculovirus infected Sf9 cells using cAMP as substrate pretreated for 10 mins followed by substrate addition and measured after 40 mins by kinase-Glo luminescence assay | Homo sapiens | 54 | ALA4152287 | cell-based format | Scientific Literature | |
2. | ALA4155480 | A | Intrinsic clearance in rat liver microsomes in presence of NADP/G6P/G6P dehydrogenase/MgCl2 by LC/MS analysis | Rattus norvegicus | 14 | ALA4152287 | microsome format | Scientific Literature | |
3. | ALA4155481 | A | Intrinsic clearance in human liver microsomes in presence of NADP/G6P/G6P dehydrogenase/MgCl2 by LC/MS analysis | Homo sapiens | 4 | ALA4152287 | microsome format | Scientific Literature | |
4. | ALA4155484 | B | Inhibition of Ca2+/calmodulin-induced recombinant human full length N-terminal GST-tagged PDE9A2 expressed in baculovirus infected Sf9 cells using cGMP as substrate pretreated for 10 mins followed by substrate addition and measured after 60 mins by kinase-Glo luminescence assay | Homo sapiens | 25 | ALA4152287 | cell-based format | Scientific Literature | |
5. | ALA4155485 | B | Inhibition of Ca2+/calmodulin-induced full-length recombinant human N-terminal GST-tagged PDE1C expressed in baculovirus infected Sf9 insect cells using cAMP as substrate pretreated for 10 mins followed by substrate addition and measured after 30 mins by kinase-Glo luminescence assay | Homo sapiens | 25 | ALA4152287 | cell-based format | Scientific Literature | |
6. | ALA4155486 | B | Inhibition of recombinant human N-terminal GST-tagged PDE1C (2 to 634 residues) expressed in baculovirus infected Sf9 cells at 100 nM using iFl-cAMP/iFl-cGMP as substrate by mobility shift assay relative to control | Homo sapiens | 2 | ALA4152287 | cell-based format | Scientific Literature | |
7. | ALA4155487 | B | Inhibition of rat PDE2A expressed in baculovirus infected Sf9 cells at 100 nM using iFl-cAMP/iFl-cGMP as substrate by mobility shift assay relative to control | Rattus norvegicus | 2 | ALA4152287 | cell-based format | Scientific Literature | |
8. | ALA4155488 | B | Inhibition of recombinant human N-terminal GST-tagged PDE3B (592 to end residues) expressed in baculovirus infected Sf9 cells at 100 nM using iFl-cAMP/iFl-cGMP as substrate by mobility shift assay relative to control | Homo sapiens | 2 | ALA4152287 | cell-based format | Scientific Literature | |
9. | ALA4155489 | B | Inhibition of recombinant full length human N-terminal GST-tagged PDE4B1 expressed in baculovirus infected Sf9 cells at 100 nM using iFl-cAMP/iFl-cGMP as substrate by mobility shift assay relative to control | Homo sapiens | 2 | ALA4152287 | cell-based format | Scientific Literature | |
10. | ALA4155490 | B | Inhibition of PDE5A1 (unknown origin) at 100 nM using iFl-cAMP/iFl-cGMP as substrate by mobility shift assay relative to control | Homo sapiens | 2 | ALA4152287 | single protein format | Scientific Literature | |
11. | ALA4155491 | B | Inhibition of PDE6C (unknown origin) at 100 nM using iFl-cAMP/iFl-cGMP as substrate by mobility shift assay relative to control | Homo sapiens | 2 | ALA4152287 | single protein format | Scientific Literature | |
12. | ALA4155492 | B | Inhibition of PDE7A (unknown origin) at 100 nM using iFl-cAMP/iFl-cGMP as substrate by mobility shift assay relative to control | Homo sapiens | 2 | ALA4152287 | single protein format | Scientific Literature | |
13. | ALA4155493 | B | Inhibition of recombinant full length human N-terminal GST-tagged PDE8A1 expressed in baculovirus infected Sf9 cells at 100 nM using iFl-cAMP/iFl-cGMP as substrate by mobility shift assay relative to control | Homo sapiens | 2 | ALA4152287 | cell-based format | Scientific Literature | |
14. | ALA4155494 | B | Inhibition of recombinant full length human N-terminal GST-tagged PDE9A2 expressed in baculovirus infected Sf9 cells at 100 nM using iFl-cAMP/iFl-cGMP as substrate by mobility shift assay relative to control | Homo sapiens | 2 | ALA4152287 | cell-based format | Scientific Literature | |
15. | ALA4155495 | B | Inhibition of recombinant human N-terminal GST-tagged PDE10A1 ( 2 to 789 residues) expressed in baculovirus infected Sf9 cells at 100 nM using iFl-cAMP/iFl-cGMP as substrate by mobility shift assay relative to control | Homo sapiens | 2 | ALA4152287 | cell-based format | Scientific Literature | |
16. | ALA4155496 | B | Inhibition of recombinant mouse N-terminal GST-tagged PDE11A (2 to 933 residues) expressed in baculovirus infected Sf9 cells at 100 nM using iFl-cAMP/iFl-cGMP as substrate by mobility shift assay relative to control | Mus musculus | 2 | ALA4152287 | cell-based format | Scientific Literature |