# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4151220 | Binding | Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity measured after 24 hrs | Homo sapiens | 33 | ALA4145662 | cell-based format | Scientific Literature | |
2. | ALA4151221 | ADME | Agonist activity at PR in human T47D cells at 10 uM | Homo sapiens | 6 | ALA4145662 | cell-based format | Scientific Literature | |
3. | ALA4151222 | Binding | Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced beta1-Na/K-ATPase expression at 0.1 to 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA4145662 | cell-based format | Scientific Literature | |
4. | ALA4151225 | Binding | Displacement of [1,2,6,7-3H]progesterone from recombinant human GST-tagged PGR LBD (678 to 933 residues) expressed in baculovirus-infected insect cells measured after 24 hrs by liquid scintillation counting method | Homo sapiens | 4 | ALA4145662 | cell-based format | Scientific Literature | |
5. | ALA4151226 | Binding | Antagonist activity at human RORalpha1 expressed in HEK293 cells at 20 uM after 24 hrs by luciferase reporter gene assay | Homo sapiens | 3 | ALA4145662 | cell-based format | Scientific Literature | |
6. | ALA4151227 | Binding | Antagonist activity at human RORbeta1 expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay | Homo sapiens | 3 | ALA4145662 | cell-based format | Scientific Literature | |
7. | ALA4151229 | Binding | Antagonist activity at human GAL4N-fused LXRalpha LBD expressed in HEK293 cells assessed as reduction in T0901317-induced transactivation activity after 24 hrs by luciferase reporter gene assay | Homo sapiens | 3 | ALA4145662 | cell-based format | Scientific Literature | |
8. | ALA4151231 | ADME | Antagonist activity at human CMX-AR expressed in HEK293 cells assessed as reduction in dihydrotestosterone-induced transactivation activity after 24 hrs by luciferase reporter gene assay | Homo sapiens | 3 | ALA4145662 | cell-based format | Scientific Literature | |
9. | ALA4151232 | ADME | Antagonist activity at human CMX-GRalpha expressed in HEK293 cells assessed as reduction in dexamethasone-induced transactivation activity after 24 hrs by luciferase reporter gene assay | Homo sapiens | 3 | ALA4145662 | cell-based format | Scientific Literature | |
10. | ALA4151233 | Binding | Antagonist activity at human RORgamma1 expressed in HEK293 cells at 20 uM after 24 hrs by luciferase reporter gene assay | Homo sapiens | 2 | ALA4145662 | cell-based format | Scientific Literature | |
11. | ALA4151234 | Binding | Antagonist activity at human GAL4N-fused LXRbeta LBD expressed in HEK293 cells assessed as reduction in T0901317-induced transactivation activity at 20 uM after 24 hrs by luciferase reporter gene assay | Homo sapiens | 1 | ALA4145662 | cell-based format | Scientific Literature | |
12. | ALA4151235 | Binding | Selectivity ratio of IC50 for human RORalpha1 expressed in HEK293 cells to IC50 for PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity | Homo sapiens | 3 | ALA4145662 | cell-based format | Scientific Literature | |
13. | ALA4151236 | Binding | Selectivity ratio of IC50 for human RORbeta1 expressed in HEK293 cells to IC50 for PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity | Homo sapiens | 3 | ALA4145662 | cell-based format | Scientific Literature | |
14. | ALA4151237 | Binding | Selectivity ratio of IC50 for human RORgamma1 expressed in HEK293 cells to IC50 for PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity | Homo sapiens | 3 | ALA4145662 | cell-based format | Scientific Literature | |
15. | ALA4151238 | Binding | Selectivity ratio of IC50 for human GAL4N-fused LXRalpha LBD expressed in HEK293 cells to IC50 for PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity | Homo sapiens | 3 | ALA4145662 | cell-based format | Scientific Literature | |
16. | ALA4151239 | Binding | Selectivity ratio of IC50 for human GAL4N-fused LXRbeta LBD expressed in HEK293 cells to IC50 for PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity | Homo sapiens | 3 | ALA4145662 | cell-based format | Scientific Literature | |
17. | ALA4151240 | Binding | Selectivity ratio of IC50 for human CMX-AR expressed in HEK293 cells to IC50 for PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity | Homo sapiens | 3 | ALA4145662 | cell-based format | Scientific Literature | |
18. | ALA4151241 | Binding | Selectivity ratio of IC50 for human CMX-GRalpha expressed in HEK293 cells to IC50 for PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity | Homo sapiens | 3 | ALA4145662 | cell-based format | Scientific Literature |