| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4154432 | Binding | Inhibition of His-tagged BRD4 bromodomain-1 (unknown origin) expressed in Escherichia coli BL21(DE3) using SGRGK(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K-Biotin as substrate preincubated for 15 mins followed by substrate addition measured after 10 mins by Alphascreen assay | Homo sapiens | 52 | ALA4152245 | assay format | Scientific Literature | |
| 2. | ALA4154433 | Binding | Inhibition of His-tagged BRD4 bromodomain-1 (unknown origin) expressed in Escherichia coli BL21(DE3) at 20 uM using SGRGK(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K-Biotin as substrate preincubated for 15 mins followed by substrate addition measured after 10 mins by Alphascreen assay relative to control | Homo sapiens | 51 | ALA4152245 | assay format | Scientific Literature | |
| 3. | ALA4154434 | Binding | Inhibition of His-tagged BRD4 bromodomain-1 (unknown origin) expressed in Escherichia coli BL21(DE3) at 5 uM using SGRGK(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K-Biotin as substrate preincubated for 15 mins followed by substrate addition measured after 10 mins by Alphascreen assay relative to control | Homo sapiens | 51 | ALA4152245 | assay format | Scientific Literature | |
| 4. | ALA4154436 | Binding | Binding affinity to His-tagged BRD4 bromodomain-1 (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as change in melting temperature at 100 uM by SYPRO orange dye based thermal shift assay | Homo sapiens | 5 | ALA4152245 | assay format | Scientific Literature | |
| 5. | ALA4154437 | Functional | Antiproliferative activity against human MV4-11 cells after 72 hrs by CellTiter-Glo luminescent assay | Homo sapiens | 3 | ALA4152245 | cell-based format | Scientific Literature | |
| 6. | ALA4154438 | ADME | Antiproliferative activity against HUVEC after 72 hrs by CellTiter-Glo luminescent assay | Homo sapiens | 3 | ALA4152245 | cell-based format | Scientific Literature | |
| 7. | ALA4154439 | ADME | Antiproliferative activity against human MRC5 cells after 72 hrs by CellTiter-Glo luminescent assay | Homo sapiens | 3 | ALA4152245 | cell-based format | Scientific Literature | |
| 8. | ALA4154440 | ADME | Antiproliferative activity against human RPTEC cells after 72 hrs by CellTiter-Glo luminescent assay | Homo sapiens | 3 | ALA4152245 | cell-based format | Scientific Literature | |
| 9. | ALA4154441 | Functional | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter-Glo luminescent assay | Homo sapiens | 3 | ALA4152245 | cell-based format | Scientific Literature | |
| 10. | ALA4154442 | Functional | Antiproliferative activity against human A549 cells after 72 hrs by CellTiter-Glo luminescent assay | Homo sapiens | 3 | ALA4152245 | cell-based format | Scientific Literature | |
| 11. | ALA4154443 | Functional | Antiproliferative activity against human 22Rv1 cells after 72 hrs by CellTiter-Glo luminescent assay | Homo sapiens | 3 | ALA4152245 | cell-based format | Scientific Literature | |
| 12. | ALA4154444 | Functional | Cell cycle arrest in human MV4-11 cells assessed as accumulation at G1-phase after 24 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 3 | ALA4152245 | cell-based format | Scientific Literature | |
| 13. | ALA4154445 | Functional | Cell cycle arrest in human MV4-11 cells assessed as accumulation at G1-phase at 5 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 61.39 to 63.23%) | Homo sapiens | 3 | ALA4152245 | cell-based format | Scientific Literature | |
| 14. | ALA4154446 | Functional | Cell cycle arrest in human MV4-11 cells assessed as accumulation at G2-phase at 5 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 7.76 to 8.93%) | Homo sapiens | 3 | ALA4152245 | cell-based format | Scientific Literature | |
| 15. | ALA4154447 | Functional | Cell cycle arrest in human MV4-11 cells assessed as accumulation at S-phase at 5 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 28.91 to 29.71%) | Homo sapiens | 3 | ALA4152245 | cell-based format | Scientific Literature | |
| 16. | ALA4154448 | Functional | Cell cycle arrest in human MV4-11 cells assessed as accumulation at G1-phase at 10 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 61.39 to 63.23%) | Homo sapiens | 3 | ALA4152245 | cell-based format | Scientific Literature | |
| 17. | ALA4154449 | Functional | Cell cycle arrest in human MV4-11 cells assessed as accumulation at G2-phase at 10 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 7.76 to 8.93%) | Homo sapiens | 3 | ALA4152245 | cell-based format | Scientific Literature | |
| 18. | ALA4154450 | Functional | Cell cycle arrest in human MV4-11 cells assessed as accumulation at S-phase at 10 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 28.91 to 29.71%) | Homo sapiens | 3 | ALA4152245 | cell-based format | Scientific Literature | |
| 19. | ALA4154451 | Functional | Cell cycle arrest in human MV4-11 cells assessed as accumulation at G1-phase at 20 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 61.39 to 63.23%) | Homo sapiens | 3 | ALA4152245 | cell-based format | Scientific Literature | |
| 20. | ALA4154452 | Functional | Cell cycle arrest in human MV4-11 cells assessed as accumulation at G2-phase at 20 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 7.76 to 8.93%) | Homo sapiens | 3 | ALA4152245 | cell-based format | Scientific Literature |
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