Drug metabolism in mouse plasma assessed as formation of (3R,6R,9S,12R,15S)-3,9-dibenzyl-6,12-bis((1-butyl-1H-indol-3-yl)methyl)-15-isobutyl-4,7,10,13-tetraoxo-2,5,8,11,14-pentaazahexadecan-16-oic acid at 400 ug/ml after 48 hrs by mass spectrophotometric method
Induction of apoptosis in human H69 cells assessed as loss of plasma membrane integrity at 6 uM after 48 hrs by acridine orange/ethidium bromide staining-based inverted fluorescence microscopic method
Induction of apoptosis in human DMS79 cells assessed as loss of plasma membrane integrity at 6 uM after 48 hrs by acridine orange/ethidium bromide staining-based inverted fluorescence microscopic method
Induction of apoptosis in human H69 cells assessed as increase in late apoptotic cells at 6 uM after 48 hrs by acridine orange/ethidium bromide staining-based inverted fluorescence microscopic method
Induction of apoptosis in human DMS79 cells assessed as increase in late apoptotic cells at 6 uM after 48 hrs by acridine orange/ethidium bromide staining-based inverted fluorescence microscopic method
Induction of apoptosis in human H69 cells assessed as increase in necrotic cells at 6 uM after 48 hrs by acridine orange/ethidium bromide staining-based inverted fluorescence microscopic method
Induction of apoptosis in human DMS79 cells assessed as increase in necrotic cells at 6 uM after 48 hrs by acridine orange/ethidium bromide staining-based inverted fluorescence microscopic method
Induction of apoptosis in human H69 cells assessed as cell shrinkage at 6 uM after 48 hrs by acridine orange/ethidium bromide staining-based inverted fluorescence microscopic method
Induction of apoptosis in human DMS79 cells assessed as cell shrinkage at 6 uM after 48 hrs by acridine orange/ethidium bromide staining-based inverted fluorescence microscopic method
Induction of apoptosis in human H69 cells assessed as chromatin condensation at 6 uM after 48 hrs by acridine orange/ethidium bromide staining-based inverted fluorescence microscopic method
Induction of apoptosis in human DMS79 cells assessed as chromatin condensation at 6 uM after 48 hrs by acridine orange/ethidium bromide staining-based inverted fluorescence microscopic method
Induction of apoptosis in human DMS79 cells assessed as early apoptotic cells at 2 uM after 24 hrs by Annexin V/SYTOX Blue staining-based flow cytometric method (Rvb = 6.4 +/- 0.4%)
Induction of apoptosis in human DMS79 cells assessed as late apoptotic cells at 2 uM after 24 hrs by Annexin V/SYTOX Blue staining-based flow cytometric method (Rvb = 28.6 +/- 8.2%)
Induction of apoptosis in human DMS79 cells assessed as necrotic cells at 2 uM after 24 hrs by Annexin V/SYTOX Blue staining-based flow cytometric method (Rvb = 3.3 +/- 0.6%)
Induction of apoptosis in human DMS79 cells assessed as viable cells at 2 uM after 24 hrs by Annexin V/SYTOX Blue staining-based flow cytometric method (Rvb = 61.7 +/- 9.1%)
Induction of apoptosis in human DMS79 cells assessed as early apoptotic cells at 6 uM after 24 hrs by Annexin V/SYTOX Blue staining-based flow cytometric method (Rvb = 6.4 +/- 0.4%)