# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4158209 | P | Kinetic solubility of the compound in pH 7.4 PBS buffer after 24 hrs by HPLC analysis | 8 | small-molecule physicochemical format | Scientific Literature | |||
2. | ALA4158210 | A | Permeability of the compound at 5 uM after 5 hrs by PAMPA | 8 | assay format | Scientific Literature | |||
3. | ALA4158211 | A | Half life in human liver microsomes at 1 uM in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 46 | microsome format | Scientific Literature | ||
4. | ALA4158212 | A | Half life in rat liver microsomes at 1 uM in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 46 | microsome format | Scientific Literature | ||
5. | ALA4158213 | A | Half life in mouse liver microsomes at 1 uM in presence of NADPH by LC-MS/MS analysis | Mus musculus | 46 | microsome format | Scientific Literature | ||
6. | ALA4158214 | A | Permeability of the compound assessed as drug retention at 5 uM after 5 hrs by PAMPA | 8 | assay format | Scientific Literature | |||
7. | ALA4158215 | B | Inhibition of recombinant human full length MMP13 expressed in mouse NS0 cells using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 45 | cell-based format | Scientific Literature | ||
8. | ALA4158218 | B | Inhibition of recombinant human MMP1 expressed in mouse NS0 cells using Knight substrate preincubated for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 45 | cell-based format | Scientific Literature | ||
9. | ALA4158219 | B | Inhibition of recombinant human MMP2 using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 45 | single protein format | Scientific Literature | ||
10. | ALA4158220 | B | Inhibition of recombinant human MMP8 expressed in mouse NS0 cells using Knight substrate preincubated for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 45 | cell-based format | Scientific Literature | ||
11. | ALA4158221 | B | Inhibition of recombinant human MMP9 using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 45 | single protein format | Scientific Literature | ||
12. | ALA4158222 | B | Inhibition of recombinant human MMP14 expressed in Escherichia coli using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 45 | assay format | Scientific Literature | ||
13. | ALA4158223 | B | Selectivity ratio of IC50 for recombinant human MMP1 expressed in mouse NS0 cells to IC50 for recombinant human full length MMP13 expressed in mouse NS0 cells | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
14. | ALA4158224 | B | Selectivity ratio of IC50 for recombinant human MMP2 to IC50 for recombinant human full length MMP13 expressed in mouse NS0 cells | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
15. | ALA4158225 | B | Selectivity ratio of IC50 for recombinant human MMP8 expressed in mouse NS0 cells to IC50 for recombinant human full length MMP13 expressed in mouse NS0 cells | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
16. | ALA4158226 | B | Selectivity ratio of IC50 for recombinant human MMP9 to IC50 for recombinant human full length MMP13 expressed in mouse NS0 cells | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
17. | ALA4158227 | B | Selectivity ratio of IC50 for recombinant human MMP14 expressed in Escherichia coli to IC50 for recombinant human full length MMP13 expressed in mouse NS0 cells | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
18. | ALA4158230 | B | Inhibition of recombinant human full length MMP13 expressed in mouse NS0 cells assessed as reduction in enzyme-mediated type-2 collagen cleavage at 20 uM after 22 hrs by SDS-PAGE analysis relative to control | Homo sapiens | 32 | cell-based format | Scientific Literature | ||
19. | ALA4158231 | B | Inhibition of recombinant human full length MMP13 expressed in mouse NS0 cells assessed as reduction in enzyme-mediated type-2 collagen cleavage after 22 hrs by SDS-PAGE analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |