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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4150526 B Inhibition of CDK8 (unknown origin) Homo sapiens 27 single protein format Scientific Literature 2. ALA4150534 B Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 1 uM measured after 6 to 24 hrs by immunoblot analysis Homo sapiens 1 cell-based format Scientific Literature 3. ALA4150536 B Induction of CRBN-mediated CDK8 degradation in wild-type human MOLT4 cells at 5 uM measured after 24 hrs by immunoblot analysis Homo sapiens 1 assay format Scientific Literature 4. ALA4150537 B Induction of CDK8 degradation in human MOLT4 cells harboring CRBN deletion mutant at 0.1 to 5 uM measured after 24 hrs by immunoblot analysis Homo sapiens 1 cell-based format Scientific Literature 5. ALA4150539 B Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 1 uM measured after 6 hrs in presence of proteasome inhibitor bortezomib by immunoblot analysis Homo sapiens 1 cell-based format Scientific Literature 6. ALA4150540 B Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 1 uM measured after 6 hrs in presence of neddylation inhibitor MLN4924 by immunoblot analysis Homo sapiens 1 cell-based format Scientific Literature 7. ALA4150541 B Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 1 uM measured after 6 hrs in presence of N-((3S,17S)-17-(isoquinolin-7-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)-Nmethyl-1-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-amide by immunoblot analysis Homo sapiens 1 cell-based format Scientific Literature 8. ALA4150542 B Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 1 uM measured after 6 hrs in presence of lenalidomide by immunoblot analysis Homo sapiens 1 cell-based format Scientific Literature 9. ALA4150543 F Effect on CDK8 mRNA levels in human Jurkat cells at 1 uM after 24 hrs by qPCR analysis Homo sapiens 1 cell-based format Scientific Literature 10. ALA4150544 B Induction of CRBN-mediated CDK8 degradation in wild-type human Jurkat cells at 1 to 10 uM measured after 24 hrs by immunoblot analysis Homo sapiens 1 cell-based format Scientific Literature 11. ALA4150545 B Induction of CRBN-mediated CDK8 degradation in wild-type human Jurkat cells at 20 uM measured after 24 hrs by immunoblot analysis Homo sapiens 1 cell-based format Scientific Literature 12. ALA4150546 B Induction of CRBN-mediated CDK19 degradation in wild-type human Jurkat cells up to 20 uM measured after 24 hrs by immunoblot analysis Homo sapiens 1 cell-based format Scientific Literature 13. ALA4150547 B Induction of CDK19 degradation in human Jurkat cells harboring CRBN deletion mutant up to 20 uM measured after 24 hrs by immunoblot analysis Homo sapiens 1 cell-based format Scientific Literature 14. ALA4650107 B Thermal Shift Assay. Domain start/stop: M626-G740 Homo sapiens 1,014 single protein format EUbOPEN Chemogenomic Library 15. ALA4725212 T Incucyte cell viability with HEK293T Homo sapiens 1,713 cell-based format EUbOPEN Chemogenomic Library 16. ALA4725213 T Incucyte cell viability with human fibroblast Homo sapiens 1,718 cell-based format EUbOPEN Chemogenomic Library 17. ALA4725214 T Incucyte cell viability with U2OS Homo sapiens 1,712 cell-based format EUbOPEN Chemogenomic Library 18. ALA5060015 B Thermal Shift Assay. Domain: start/stop: S229-K512 Homo sapiens 1,499 single protein format EUbOPEN Chemogenomic Library 19. ALA5060944 B Thermal Shift Assay. Domain: start/stop: N44-E168 Homo sapiens 1,502 single protein format EUbOPEN Chemogenomic Library 20. ALA5062802 B Thermal Shift Assay. Domain: start/stop: M1-L298 Homo sapiens 1,499 single protein format EUbOPEN Chemogenomic Library