The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
The page will load shortly, Thanks for your patience!
# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4150526 Binding Inhibition of CDK8 (unknown origin) Homo sapiens 27 ALA4145630 single protein format Scientific Literature 2. ALA4150534 Binding Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 1 uM measured after 6 to 24 hrs by immunoblot analysis Homo sapiens 1 ALA4145630 cell-based format Scientific Literature 3. ALA4150536 Binding Induction of CRBN-mediated CDK8 degradation in wild-type human MOLT4 cells at 5 uM measured after 24 hrs by immunoblot analysis Homo sapiens 1 ALA4145630 assay format Scientific Literature 4. ALA4150537 Binding Induction of CDK8 degradation in human MOLT4 cells harboring CRBN deletion mutant at 0.1 to 5 uM measured after 24 hrs by immunoblot analysis Homo sapiens 1 ALA4145630 cell-based format Scientific Literature 5. ALA4150539 Binding Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 1 uM measured after 6 hrs in presence of proteasome inhibitor bortezomib by immunoblot analysis Homo sapiens 1 ALA4145630 cell-based format Scientific Literature 6. ALA4150540 Binding Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 1 uM measured after 6 hrs in presence of neddylation inhibitor MLN4924 by immunoblot analysis Homo sapiens 1 ALA4145630 cell-based format Scientific Literature 7. ALA4150541 Binding Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 1 uM measured after 6 hrs in presence of N-((3S,17S)-17-(isoquinolin-7-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)-Nmethyl-1-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-amide by immunoblot analysis Homo sapiens 1 ALA4145630 cell-based format Scientific Literature 8. ALA4150542 Binding Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 1 uM measured after 6 hrs in presence of lenalidomide by immunoblot analysis Homo sapiens 1 ALA4145630 cell-based format Scientific Literature 9. ALA4150543 Functional Effect on CDK8 mRNA levels in human Jurkat cells at 1 uM after 24 hrs by qPCR analysis Homo sapiens 1 ALA4145630 cell-based format Scientific Literature 10. ALA4150544 Binding Induction of CRBN-mediated CDK8 degradation in wild-type human Jurkat cells at 1 to 10 uM measured after 24 hrs by immunoblot analysis Homo sapiens 1 ALA4145630 cell-based format Scientific Literature 11. ALA4150545 Binding Induction of CRBN-mediated CDK8 degradation in wild-type human Jurkat cells at 20 uM measured after 24 hrs by immunoblot analysis Homo sapiens 1 ALA4145630 cell-based format Scientific Literature 12. ALA4150546 Binding Induction of CRBN-mediated CDK19 degradation in wild-type human Jurkat cells up to 20 uM measured after 24 hrs by immunoblot analysis Homo sapiens 1 ALA4145630 cell-based format Scientific Literature 13. ALA4150547 Binding Induction of CDK19 degradation in human Jurkat cells harboring CRBN deletion mutant up to 20 uM measured after 24 hrs by immunoblot analysis Homo sapiens 1 ALA4145630 cell-based format Scientific Literature 14. ALA4650107 Binding Thermal Shift Assay. Domain start/stop: M626-G740 Homo sapiens 1,014 ALA4649998 single protein format EUbOPEN Chemogenomic Library 15. ALA4725212 Toxicity Incucyte cell viability with HEK293T Homo sapiens 1,713 ALA4689842 cell-based format EUbOPEN Chemogenomic Library 16. ALA4725213 Toxicity Incucyte cell viability with human fibroblast Homo sapiens 1,718 ALA4689842 cell-based format EUbOPEN Chemogenomic Library 17. ALA4725214 Toxicity Incucyte cell viability with U2OS Homo sapiens 1,712 ALA4689842 cell-based format EUbOPEN Chemogenomic Library 18. ALA5060015 Binding Thermal Shift Assay. Domain: start/stop: S229-K512 Homo sapiens 1,499 ALA5060014 single protein format EUbOPEN Chemogenomic Library 19. ALA5060944 Binding Thermal Shift Assay. Domain: start/stop: N44-E168 Homo sapiens 1,502 ALA5060014 single protein format EUbOPEN Chemogenomic Library 20. ALA5062802 Binding Thermal Shift Assay. Domain: start/stop: M1-L298 Homo sapiens 1,499 ALA5060014 single protein format EUbOPEN Chemogenomic Library