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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4157512 B Inhibition of Cy5-labeled cyclosporin A binding to full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) after 30 mins by TR-FRET assay Homo sapiens 23 ALA4152348 assay format Scientific Literature 2. ALA4157513 F Antiviral activity against HCV genotype 2a infected in human HuH7 cells after 3 days by dual-glo luciferase reporter gene assay Hepacivirus hominis 22 ALA4152348 organism-based format Scientific Literature 3. ALA4157514 A Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 4 to 5 days by cell-titer glo assay Homo sapiens 21 ALA4152348 cell-based format Scientific Literature 4. ALA4157515 A Unbound fraction in cell culture medium/buffer dialysis at 2 uM at pH 7.4 by LC/MS/MS analysis 18 ALA4152348 assay format Scientific Literature 5. ALA4157516 A Unbound fraction in human plasma at 2 uM at pH 7.4 by LC/MS/MS analysis Homo sapiens 18 ALA4152348 cell-free format Scientific Literature 6. ALA4157517 A Half life in human plasma at 2 uM up to 4 hrs by LC/MS/MS analysis Homo sapiens 11 ALA4152348 cell-free format Scientific Literature 7. ALA4157518 A Half life in dog plasma at 2 uM up to 4 hrs by LC/MS/MS analysis Canis lupus familiaris 11 ALA4152348 cell-free format Scientific Literature 8. ALA4157519 A Half life in rat plasma at 2 uM up to 4 hrs by LC/MS/MS analysis Rattus norvegicus 8 ALA4152348 cell-free format Scientific Literature 9. ALA4157520 A Apparent permeability across apical to basolateral side in human Caco2 cells measured at 60 to 120 mins by LC/MS/MS analysis Homo sapiens 17 ALA4152348 cell-based format Scientific Literature 10. ALA4157521 A Apparent permeability across basolateral to apical side in human Caco2 cells measured at 60 to 120 mins by LC/MS/MS analysis Homo sapiens 17 ALA4152348 cell-based format Scientific Literature 11. ALA4157522 P Lipophilicity, log D of the compound at pH 7.4 after 30 mins by HPLC/UV analysis 17 ALA4152348 small-molecule physicochemical format Scientific Literature 12. ALA4157523 A Activation of human full length PXR expressed in human HepG2 cells at 1.5 uM after 48 hrs by luciferase assay relative to control Homo sapiens 7 ALA4152348 cell-based format Scientific Literature 13. ALA4157524 A Activation of human full length PXR expressed in human HepG2 cells at 15 uM after 48 hrs by luciferase assay relative to rifampicin Homo sapiens 7 ALA4152348 cell-based format Scientific Literature 14. ALA4157528 A Clearance in Beagle dog at 1 mg/kg, iv or 5 mg/kg, po by HPLC/MS analysis Canis lupus familiaris 2 ALA4152348 organism-based format Scientific Literature 15. ALA4157530 A Volume of distribution at steady state in Beagle dog at 1 mg/kg, iv or 5 mg/kg, po by HPLC/MS analysis Canis lupus familiaris 2 ALA4152348 organism-based format Scientific Literature 16. ALA4157532 A Terminal half life in Beagle dog at 1 mg/kg, iv or 5 mg/kg, po by HPLC/MS analysis Canis lupus familiaris 2 ALA4152348 organism-based format Scientific Literature 17. ALA4157534 A Oral bioavailability in Beagle dog at 5 mg/kg by HPLC/MS analysis Canis lupus familiaris 3 ALA4152348 organism-based format Scientific Literature 18. ALA4157538 A Clearance in Sprague-Dawley rat at 10 mg/kg, iv or 10 mg/kg, po by HPLC/MS analysis Rattus norvegicus 1 ALA4152348 organism-based format Scientific Literature 19. ALA4157539 A Volume of distribution at steady state in Sprague-Dawley rat at 10 mg/kg, iv or 10 mg/kg, po by HPLC/MS analysis Rattus norvegicus 1 ALA4152348 organism-based format Scientific Literature 20. ALA4157540 A Terminal half life in Sprague-Dawley rat at 10 mg/kg, iv or 10 mg/kg, po by HPLC/MS analysis Rattus norvegicus 1 ALA4152348 organism-based format Scientific Literature