# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4150900 | ADME | Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by UPLC-MS analysis | Homo sapiens | 37 | ALA4145649 | microsome format | Scientific Literature | |
2. | ALA4150901 | ADME | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by UPLC-MS analysis | Homo sapiens | 37 | ALA4145649 | microsome format | Scientific Literature | |
3. | ALA4150902 | ADME | Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by UPLC-MS analysis | Homo sapiens | 37 | ALA4145649 | microsome format | Scientific Literature | |
4. | ALA4150903 | ADME | Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by UPLC-MS analysis | Homo sapiens | 37 | ALA4145649 | microsome format | Scientific Literature | |
5. | ALA4150904 | ADME | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by UPLC-MS analysis | Homo sapiens | 37 | ALA4145649 | microsome format | Scientific Literature | |
6. | ALA4150905 | ADME | Inhibition of CYP2C19 in human liver microsomes using omeprazole as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by UPLC-MS analysis | Homo sapiens | 37 | ALA4145649 | microsome format | Scientific Literature | |
7. | ALA4150906 | ADME | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by UPLC-MS analysis | Homo sapiens | 37 | ALA4145649 | microsome format | Scientific Literature | |
8. | ALA4150907 | ADME | Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by UPLC-MS analysis | Homo sapiens | 37 | ALA4145649 | microsome format | Scientific Literature | |
9. | ALA4150908 | ADME | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by UPLC-MS analysis | Homo sapiens | 37 | ALA4145649 | microsome format | Scientific Literature | |
10. | ALA4150909 | Binding | Selectivity index, ratio of IC50 for CYP3A4 in human liver microsomes to IC50 for CYP2A6 in human liver microsomes | Homo sapiens | 37 | ALA4145649 | assay format | Scientific Literature | |
11. | ALA4150910 | Binding | Selectivity index, ratio of IC50 for CYP2D6 in human liver microsomes to IC50 for CYP2A6 in human liver microsomes | Homo sapiens | 37 | ALA4145649 | assay format | Scientific Literature | |
12. | ALA4150911 | Binding | Selectivity index, ratio of IC50 for CYP2C9 in human liver microsomes to IC50 for CYP2A6 in human liver microsomes | Homo sapiens | 37 | ALA4145649 | assay format | Scientific Literature | |
13. | ALA4150912 | Binding | Selectivity index, ratio of IC50 for CYP2C19 in human liver microsomes to IC50 for CYP2A6 in human liver microsomes | Homo sapiens | 37 | ALA4145649 | assay format | Scientific Literature | |
14. | ALA4150913 | Binding | Selectivity index, ratio of IC50 for CYP1A2 in human liver microsomes to IC50 for CYP2A6 in human liver microsomes | Homo sapiens | 37 | ALA4145649 | assay format | Scientific Literature | |
15. | ALA4150914 | Binding | Selectivity index, ratio of IC50 for CYP2B6 in human liver microsomes to IC50 for CYP2A6 in human liver microsomes | Homo sapiens | 37 | ALA4145649 | assay format | Scientific Literature | |
16. | ALA4150915 | Binding | Selectivity index, ratio of IC50 for CYP2C8 in human liver microsomes to IC50 for CYP2A6 in human liver microsomes | Homo sapiens | 37 | ALA4145649 | assay format | Scientific Literature | |
17. | ALA4150916 | Binding | Selectivity index, ratio of IC50 for CYP2E1 in human liver microsomes to IC50 for CYP2A6 in human liver microsomes | Homo sapiens | 37 | ALA4145649 | assay format | Scientific Literature | |
18. | ALA4150917 | ADME | Half life in human liver microsomes at 10 uM up to 2 hrs at 37 degC in presence of NADPH-regenerating system by UPLC/MS analysis | Homo sapiens | 18 | ALA4145649 | microsome format | Scientific Literature |