# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4201008 | B | Inhibition of ACK1 (unknown origin) by radiometric biochemical kinase assay | Homo sapiens | 30 | single protein format | Scientific Literature | ||
2. | ALA4201009 | B | Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay | Homo sapiens | 30 | single protein format | Scientific Literature | ||
3. | ALA4201010 | A | Growth inhibition of parental mouse BA/F3 cells after 72 hrs by celltiter-glo assay | Mus musculus | 30 | cell-based format | Scientific Literature | ||
4. | ALA4201011 | B | Inhibition of ACK1/GCK in mouse BA/F3 cells assessed as reduction in NRAS-G12D mutant-mediated cell proliferation after 72 hrs by celltiter-glo assay | Mus musculus | 30 | cell-based format | Scientific Literature | ||
5. | ALA4201012 | F | Growth inhibition of human OCI-AML3 cells harboring NRAS-Q61L mutant after 72 hrs by celltiter-glo assay | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
6. | ALA4201013 | A | Growth inhibition of parental human U937 cells after 72 hrs by celltiter-glo assay | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
7. | ALA4201014 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 30 mins | Homo sapiens | 9 | microsome format | Scientific Literature | ||
8. | ALA4201015 | A | Metabolic stability in dog liver microsomes assessed as compound remaining at 1 uM after 30 mins | Canis lupus familiaris | 9 | microsome format | Scientific Literature | ||
9. | ALA4201016 | A | Metabolic stability in rat liver microsomes assessed as compound remaining at 1 uM after 30 mins | Rattus norvegicus | 9 | microsome format | Scientific Literature | ||
10. | ALA4201017 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining at 1 uM after 30 mins | Mus musculus | 9 | microsome format | Scientific Literature | ||
11. | ALA4201018 | A | Inhibition of CYP1A2 (unknown origin) assessed as activity remaining at 10 uM relative to control | Homo sapiens | 9 | single protein format | Scientific Literature | ||
12. | ALA4201019 | A | Inhibition of CYP2C9 (unknown origin) assessed as activity remaining at 10 uM relative to control | Homo sapiens | 9 | single protein format | Scientific Literature | ||
13. | ALA4201020 | A | Inhibition of CYP2D6 (unknown origin) assessed as activity remaining at 10 uM relative to control | Homo sapiens | 9 | single protein format | Scientific Literature | ||
14. | ALA4201021 | A | Inhibition of CYP3A4 (unknown origin) assessed as activity remaining at 10 uM relative to control | Homo sapiens | 9 | single protein format | Scientific Literature | ||
15. | ALA4201028 | B | Inhibition of ACK1 in mouse BA/F3 cells harboring NRAS-G12D mutant assessed as reduction in P70S6K1 phosphorylation at Thr421/Ser424 at 1 uM after 2 hrs by Western blot analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
16. | ALA4201029 | B | Inhibition of ACK1 in mouse BA/F3 cells harboring NRAS-G12D mutant assessed as reduction in AKT phosphorylation at S473 at 1 uM after 2 hrs by Western blot analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
17. | ALA4201030 | B | Inhibition of GCK in mouse BA/F3 cells harboring NRAS-G12D mutant assessed as reduction in JNK phosphorylation at T183/Y185 at 1 uM after 2 hrs by Western blot analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
18. | ALA4201031 | B | Inhibition of GCK in mouse BA/F3 cells harboring NRAS-G12D mutant assessed as reduction in p38 phosphorylation at Thr180/Tyr182 at 1 uM after 2 hrs by Western blot analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
19. | ALA4201032 | B | Inhibition of ACK1 in human OCI-AML3 cells harboring NRAS Q61L mutant assessed as reduction in P70S6K1 phosphorylation at Thr421/Ser424 at 1 uM after 2 hrs by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
20. | ALA4201033 | B | Inhibition of ACK1 in human OCI-AML3 cells harboring NRAS Q61L mutant assessed as reduction in AKT phosphorylation at S473 at 1 uM after 2 hrs by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature |