# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4200879 | P | Solubility in FeSSIF solution at 1 mg/ml at pH 6.5 by HPLC with UV detector based assay | 3 | small-molecule physicochemical format | Scientific Literature | |||
2. | ALA4200880 | F | Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay | Mus musculus | 67 | cell-based format | Scientific Literature | ||
3. | ALA4200881 | F | Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay relative to NTX2048 | Mus musculus | 67 | cell-based format | Scientific Literature | ||
4. | ALA4200882 | F | Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
5. | ALA4200883 | F | Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay relative to NTX2048 | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
6. | ALA4200884 | F | Increase in total plasma GLP1 level in C57BL/6 mouse at 30 mg/kg, po measured after 8 hrs relative to untreated vehicle control | Mus musculus | 22 | organism-based format | Scientific Literature | ||
7. | ALA4200885 | T | Toxicity in C57BL/6 mouse assessed as induction of excessive gallbladder filling by measuring gal bladder weight at 30 mg/kg, po measured after 8 hrs relative to untreated vehicle control | Mus musculus | 22 | organism-based format | Scientific Literature | ||
8. | ALA4200886 | A | Drug concentration in bile/gall bladder of C57BL/6 mouse at 30 mg/kg, po measured after 8 hrs by HPLC and mass spectrometry | Mus musculus | 22 | organism-based format | Scientific Literature | ||
9. | ALA4200887 | A | Plasma concentration in C57BL/6 mouse at 30 mg/kg, po measured after 8 hrs by HPLC and mass spectrometry | Mus musculus | 22 | organism-based format | Scientific Literature | ||
10. | ALA4200888 | B | Activation of human FXR up to 50 uM | Homo sapiens | 3 | single protein format | Scientific Literature | ||
11. | ALA4200889 | B | Activation of human FXR | Homo sapiens | 3 | single protein format | Scientific Literature | ||
12. | ALA4200890 | B | Inhibition of human IBAT expressed in COS cells assessed as reduction in [3H]taurocholic acid uptake | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
13. | ALA4200891 | B | Inhibition of mouse IBAT expressed in COS cells assessed as reduction in [3H]taurocholic acid uptake | Mus musculus | 3 | cell-based format | Scientific Literature | ||
14. | ALA4200892 | A | Cmax in C57BL/6 mouse plasma at 10 mg/kg, po by HPLC and mass spectrometry | Mus musculus | 1 | organism-based format | Scientific Literature | ||
15. | ALA4200893 | A | AUC in C57BL/6 mouse plasma at 10 mg/kg, po by HPLC and mass spectrometry | Mus musculus | 1 | organism-based format | Scientific Literature | ||
16. | ALA4200894 | A | Drug recovery in C57BL/6 mouse feces at 10 mg/kg, po after 48 hrs by LC-MS/MS method | Mus musculus | 1 | organism-based format | Scientific Literature | ||
17. | ALA4200895 | A | Drug recovery in C57BL/6 mouse bile/gall bladder at 30 mg/kg, po by LC-MS/MS method | Mus musculus | 1 | organism-based format | Scientific Literature | ||
18. | ALA4200896 | A | Apparent permeability from apical to basolateral side in MDCK cells at 10 uM by HPLC-MS/MS method | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
19. | ALA4200897 | A | Apparent permeability from basolateral to apical side in MDCK cells at 10 uM by HPLC-MS/MS method | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
20. | ALA4200898 | A | Efflux ratio in MDCK cells at 10 uM by HPLC-MS/MS method | Canis lupus familiaris | 1 | cell-based format | Scientific Literature |