# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4181719 | Binding | Inhibition of recombinant Cav3.1 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by CaCl2 addition by Fluo-4-AM dye-based FLIPR assay | Homo sapiens | 75 | ALA4177680 | cell-based format | Scientific Literature | |
2. | ALA4181720 | Binding | Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by CaCl2 addition by Fluo-4-AM dye-based FLIPR assay | Homo sapiens | 75 | ALA4177680 | cell-based format | Scientific Literature | |
3. | ALA4181721 | Binding | Inhibition of recombinant Cav3.3 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by CaCl2 addition by Fluo-4-AM dye-based FLIPR assay | Homo sapiens | 75 | ALA4177680 | cell-based format | Scientific Literature | |
4. | ALA4181725 | Physicochemical | Solubility of the compound in phosphate buffer at pH 7 after 24 hrs by HPLC/UV method | 32 | ALA4177680 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4181730 | ADME | Apparent permeability across apical to basolateral side in MDCK cells expressing MDR1 at 1 uM measured every 30 mins for 2 hrs | Canis lupus familiaris | 9 | ALA4177680 | cell-based format | Scientific Literature | |
6. | ALA4181731 | ADME | Efflux ratio of apparent permeability across basolateral to apical over apical to basolateral side in MDCK cells expressing MDR1 at 1 uM | Canis lupus familiaris | 11 | ALA4177680 | cell-based format | Scientific Literature | |
7. | ALA4181741 | ADME | Apparent permeability across basolateral to apical side in MDCK cells expressing MDR1 at 1 uM measured every 30 mins for 2 hrs | Canis lupus familiaris | 10 | ALA4177680 | cell-based format | Scientific Literature |