| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4182504 | P | Chemical stability of the compound in pH 6 to 8 PBS at 100 uM after 24 hrs by RP-HPLC analysis | 4 | ALA4177717 | small-molecule physicochemical format | Scientific Literature | ||
| 2. | ALA4182505 | P | Chemical stability of the compound in pH >8 solution at 100 uM after 24 hrs by RP-HPLC analysis | 4 | ALA4177717 | small-molecule physicochemical format | Scientific Literature | ||
| 3. | ALA4182506 | B | Inhibition of recombinant His6/SUMO-tagged human cN3B (1 to 300 residues) expressed in Escherichia coli BL21(DE3) RIL assessed as reduction in dephosphorylation of m7GMP substrate after 45 mins by malachite green dye based assay | Homo sapiens | 1 | ALA4177717 | assay format | Scientific Literature | |
| 4. | ALA4182507 | B | Inhibition of recombinant His6/SUMO-tagged human cN3B (1 to 300 residues) expressed in Escherichia coli BL21(DE3) RIL assessed as reduction in dephosphorylation of m7GMP substrate after 45 mins by HPLC method | Homo sapiens | 1 | ALA4177717 | assay format | Scientific Literature | |
| 5. | ALA4182508 | B | Inhibition of recombinant His6/SUMO-tagged human cN3B (1 to 300 residues) expressed in Escherichia coli BL21(DE3) RIL assessed as reduction in dephosphorylation of m7GMP substrate at 200 uM after 45 mins by HPLC method relative to control | Homo sapiens | 4 | ALA4177717 | assay format | Scientific Literature | |
| 6. | ALA4182509 | B | Inhibition of recombinant His6/SUMO-tagged human cN3B (1 to 300 residues) expressed in Escherichia coli BL21(DE3) RIL assessed as reduction in dephosphorylation of m7GMP substrate at 200 uM after 45 mins by malachite green dye based assay relative to control | Homo sapiens | 3 | ALA4177717 | assay format | Scientific Literature | |
| 7. | ALA4182512 | B | Substrate activity at recombinant His6/SUMO-tagged human cN3B (1 to 300 residues) expressed in Escherichia coli BL21(DE3) RIL assessed as compound dephosphorylation at 100 uM up to 150 mins by HPLC method | Homo sapiens | 5 | ALA4177717 | assay format | Scientific Literature | |
| 8. | ALA4182515 | B | Inhibition of fluorescein-labeled m7GDPC4H5 binding to mouse eIF4E (28 to 217 residues) by MST method | Mus musculus | 5 | ALA4177717 | single protein format | Scientific Literature | |
| 9. | ALA4182516 | B | Inhibition of human DCPS using m7GMPF as substrate after 30 mins by nucleoside 5'-fluorophosphate probe based HTS assay | Homo sapiens | 6 | ALA4177717 | single protein format | Scientific Literature | |
| 10. | ALA4182517 | B | Inhibition of eIF4E (unknown origin) | Homo sapiens | 1 | ALA4177717 | single protein format | Scientific Literature | |
| 11. | ALA4182518 | B | Selectivity ratio of IC50 for human DCPS to IC50 for recombinant His6/SUMO-tagged human cN3B (1 to 300 residues) expressed in Escherichia coli BL21(DE3) RIL | Homo sapiens | 1 | ALA4177717 | assay format | Scientific Literature | |
| 12. | ALA4182519 | B | Inhibition of recombinant His6/SUMO-tagged human cN3B (1 to 300 residues) expressed in Escherichia coli BL21(DE3) RIL assessed as reduction in conversion of m7GMP to m7Guo at 200 uM after 45 mins in presence of human DCPS by HPLC method | Homo sapiens | 1 | ALA4177717 | assay format | Scientific Literature | |
| 13. | ALA4182520 | B | Inhibition of human DCPS using m7GMPF assessed as reduction in conversion of m7GpppG to GDP at 200 uM after 45 mins in presence of human cN3B by HPLC method | Homo sapiens | 1 | ALA4177717 | single protein format | Scientific Literature |
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