# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4188420 | B | Inhibition of HCV genotype 1b NS5B polymerase infected in human HuH7 replicon cells by luciferase reporter gene assay | Hepatitis C virus subtype 1b | 71 | ALA4184265 | cell-based format | Scientific Literature | |
2. | ALA4188422 | B | Inhibition of HCV genotype 1a NS5A polymerase infected in human HuH7 replicon cells by luciferase reporter gene assay | Hepatitis C virus subtype 1b | 38 | ALA4184265 | cell-based format | Scientific Literature | |
3. | ALA4188424 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining after 60 mins | Rattus norvegicus | 7 | ALA4184265 | microsome format | Scientific Literature | |
4. | ALA4188425 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining after 60 mins | Homo sapiens | 7 | ALA4184265 | microsome format | Scientific Literature | |
5. | ALA4188426 | B | Inhibition of HCV genotype 2a NS5B polymerase infected in human HuH7 replicon cells by luciferase reporter gene assay | Hepatitis C virus subtype 2a | 7 | ALA4184265 | cell-based format | Scientific Literature | |
6. | ALA4188427 | B | Inhibition of HCV genotype 3a NS5B polymerase infected in human HuH7 replicon cells by luciferase reporter gene assay | Hepatitis C virus subtype 3a | 7 | ALA4184265 | cell-based format | Scientific Literature | |
7. | ALA4188428 | B | Inhibition of HCV genotype 4a NS5B polymerase infected in human HuH7 replicon cells by luciferase reporter gene assay | Hepatitis C virus subtype 4a | 7 | ALA4184265 | cell-based format | Scientific Literature | |
8. | ALA4188430 | A | Cytotoxicity against human HuH7 cells after 24 hrs | Homo sapiens | 2 | ALA4184265 | cell-based format | Scientific Literature | |
9. | ALA4188431 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 7 | ALA4184265 | organism-based format | Scientific Literature | |
10. | ALA4188432 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 7 | ALA4184265 | organism-based format | Scientific Literature | |
11. | ALA4188433 | A | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 7 | ALA4184265 | organism-based format | Scientific Literature | |
12. | ALA4188434 | A | AUC (infinity) in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 7 | ALA4184265 | organism-based format | Scientific Literature | |
13. | ALA4188435 | A | Oral bioavailability in Sprague-Dawley rat at 5 mg/kg | Rattus norvegicus | 7 | ALA4184265 | organism-based format | Scientific Literature |