| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4198468 | B | Inhibition of human BRDT bromodomain 1 (21 to 137 residues) expressed in Escherichia coli BL21 assessed as residual activity at 1 uM after 1 hr by BROMOScan assay relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 2. | ALA4198469 | B | Inhibition of BRD4 in human TY82 cells assessed as reduction in c-Myc protein expression at 0.2 to 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 3. | ALA4198470 | B | Displacement of FITC-JQ1 from His6-tagged BRD4 bromodomain-1 (unknown origin) expressed in Escherichia coli BL21(DE3) after 4 hrs by fluorescence anisotropy method | Homo sapiens | 44 | assay format | Scientific Literature | ||
| 4. | ALA4198471 | A | Metabolic stability in human liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured up to 30 mins by LC-MS/MS analysis | Homo sapiens | 20 | microsome format | Scientific Literature | ||
| 5. | ALA4198472 | A | Half life in human liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysis | Homo sapiens | 20 | microsome format | Scientific Literature | ||
| 6. | ALA4198473 | A | Metabolic stability in mouse liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured up to 30 mins by LC-MS/MS analysis | Mus musculus | 20 | microsome format | Scientific Literature | ||
| 7. | ALA4198474 | A | Half life in mouse liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysis | Mus musculus | 20 | microsome format | Scientific Literature | ||
| 8. | ALA4198475 | A | Inhibition of CYP3A4 in human liver microsomes at 10 uM using midazolam as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins relative to control | Homo sapiens | 20 | microsome format | Scientific Literature | ||
| 9. | ALA4198476 | A | Inhibition of CYP3A4 in human liver microsomes at 10 uM using testosterone as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins relative to control | Homo sapiens | 20 | microsome format | Scientific Literature | ||
| 10. | ALA4198477 | A | Inhibition of CYP2D6 in human liver microsomes at 10 uM using dextromethorphan as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins relative to control | Homo sapiens | 20 | microsome format | Scientific Literature | ||
| 11. | ALA4198478 | A | Inhibition of CYP2C9 in human liver microsomes at 10 uM using diclofenac as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins relative to control | Homo sapiens | 20 | microsome format | Scientific Literature | ||
| 12. | ALA4198479 | A | Inhibition of CYP1A2 in human liver microsomes at 10 uM using phenacetin as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins relative to control | Homo sapiens | 20 | microsome format | Scientific Literature | ||
| 13. | ALA4198480 | A | Inhibition of CYP2C19 in human liver microsomes at 10 uM using mephenytoin as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins relative to control | Homo sapiens | 20 | microsome format | Scientific Literature | ||
| 14. | ALA4198481 | A | Time-dependent inhibition of CYP3A4 in human liver microsomes at 10 uM using midazolam as substrate preincubated for 5 to 30 mins followed by NADPH addition measured after 10 mins | Homo sapiens | 20 | microsome format | Scientific Literature | ||
| 15. | ALA4198482 | A | Time-dependent inhibition of CYP3A4 in human liver microsomes at 10 uM using testosterone as substrate preincubated for 5 to 30 mins followed by NADPH addition measured after 10 mins | Homo sapiens | 20 | microsome format | Scientific Literature | ||
| 16. | ALA4198483 | A | Time-dependent inhibition of CYP2D6 in human liver microsomes at 10 uM using dextromethorphan as substrate preincubated for 5 to 30 mins followed by NADPH addition measured after 10 mins | Homo sapiens | 20 | microsome format | Scientific Literature | ||
| 17. | ALA4198484 | A | Time-dependent inhibition of CYP2C9 in human liver microsomes at 10 uM using diclofenac as substrate preincubated for 5 to 30 mins followed by NADPH addition measured after 10 mins | Homo sapiens | 20 | microsome format | Scientific Literature | ||
| 18. | ALA4198485 | A | Time-dependent inhibition of CYP1A2 in human liver microsomes at 10 uM using phenacetin as substrate preincubated for 5 to 30 mins followed by NADPH addition measured after 10 mins | Homo sapiens | 20 | microsome format | Scientific Literature | ||
| 19. | ALA4198486 | A | Time-dependent inhibition of CYP2C19 in human liver microsomes at 10 uM using mephenytoin as substrate preincubated for 5 to 30 mins followed by NADPH addition measured after 10 mins | Homo sapiens | 20 | microsome format | Scientific Literature | ||
| 20. | ALA4198487 | B | Inhibition of PLK1 (unknown origin) at 10 uM using Ser/Thr-16 peptide substrate after 60 mins by Z'-LYTE assay relative to control | Homo sapiens | 6 | single protein format | Scientific Literature |
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